| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Diagnostic clues in patients with clinical malabsorption and pathological small intestinal villous atrophy: Immune-mediated type and beyond
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Mu-Han Li, Qi-Pu Wang, Cheng-Zhu Ou, Tian-Ming Xu, Yang Chen, Hao Tang, Yan Zhang, Yan-Jun Lai, Xu-Zhen Qin, Ji Li, Wei-Xun Zhou and Jing-Nan Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National High-Level Hospital Clinical Research Funding |
2022-PUMCH-B-022 and 2022-PUMCH-D-002 |
| CAMS Innovation Fund for Medical Sciences |
CIFMS 2021-1-I2M-003 |
| Undergraduate Innovation Program |
2024dcxm025 |
|
| Corresponding Author |
Ji Li, MD, Professor, Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, China. liji0235@pumch.cn |
| Key Words |
Autoimmune enteropathy; Celiac disease; Diagnosis; Inborn errors of immunity; Malabsorption; Pathology; Small intestinal villous atrophy disorder |
| Core Tip |
Small intestinal villous atrophy is a key pathological feature of various rare and heterogeneous disorders associated with malabsorption. Owing to overlapping clinical, serological, and histological features among immune-mediated, lymphoproliferative, infectious, iatrogenic, inflammatory, and idiopathic causes, timely and accurate diagnosis remains challenging. This review highlights distinctive diagnostic clues and proposes a structured approach to help differentiate these entities, with the aim of improving diagnostic precision and guiding appropriate therapeutic strategies. |
| Publish Date |
2026-01-12 09:50 |
| Citation |
Li MH, Wang QP, Ou CZ, Xu TM, Chen Y, Tang H, Zhang Y, Lai YJ, Qin XZ, Li J, Zhou WX, Li JN. Diagnostic clues in patients with clinical malabsorption and pathological small intestinal villous atrophy: Immune-mediated type and beyond. World J Gastroenterol 2026; 32(2): 111996 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i2/111996.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i2.111996 |
