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Articles Published Processes
12/27/2025 2:50:53 AM | Browse: 82 | Download: 359
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Received |
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2025-07-23 06:40 |
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Peer-Review Started |
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2025-07-23 06:40 |
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First Decision by Editorial Office Director |
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2025-09-12 07:20 |
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Return for Revision |
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2025-09-12 07:20 |
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Revised |
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2025-09-20 16:14 |
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Publication Fee Transferred |
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2025-09-24 03:48 |
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Second Decision by Editor |
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2025-11-10 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-10 09:43 |
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Articles in Press |
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2025-11-10 09:43 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-16 01:46 |
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Publish the Manuscript Online |
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2025-12-27 02:50 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Critical Care Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Sphinganine inhibits macrophage polarization and protects against sepsis-induced intestinal injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Fan Chen, Ze-Tian Wang, Jian Zhao, Jian-Guo Tang and Bai-Yin Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science of Minhang District of Shanghai |
No. 2023MH2085 |
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| Corresponding Author |
Bai-Yin Zhang, PhD, Professor, PsyD, Department of Trauma-Emergency and Critical Care Medicine Center, Shanghai Fifth People’s Hospital, Fudan University, No. 801 Heqing Road, Minhang District, Shanghai 200240, China. boyinercheung@hotmail.com |
| Key Words |
Sepsis; Sphinganine; Intestinal injury; Macrophage polarization; Toll like receptor 2/nuclear factor kappa-B |
| Core Tip |
This study reveals that sphinganine protects against sepsis-induced intestinal injury by inhibiting toll like receptor 2/nuclear factor kappa-B signaling, modulating macrophage polarization toward the M2 phenotype, and preserving intestinal barrier integrity. |
| Publish Date |
2025-12-27 02:50 |
| Citation |
Chen YF, Wang ZT, Zhao J, Tang JG, Zhang BY. Sphinganine inhibits macrophage polarization and protects against sepsis-induced intestinal injury. World J Gastroenterol 2025; 31(48): 112004 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i48/112004.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i48.112004 |
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