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Articles Published Processes
1/14/2026 8:09:14 AM | Browse: 2 | Download: 14
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Received |
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2025-07-17 04:12 |
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Peer-Review Started |
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2025-07-21 00:23 |
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First Decision by Editorial Office Director |
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2025-08-08 08:00 |
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Return for Revision |
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2025-08-08 08:00 |
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Revised |
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2025-09-04 03:07 |
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Publication Fee Transferred |
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2025-09-08 07:32 |
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Second Decision by Editor |
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2025-11-28 03:01 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-28 07:12 |
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Articles in Press |
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2025-11-28 07:12 |
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Edit the Manuscript by Language Editor |
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2025-12-01 05:22 |
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Typeset the Manuscript |
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2026-01-04 02:14 |
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Publish the Manuscript Online |
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2026-01-14 08:09 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Microtubule affinity-regulating kinase 4 exacerbates diabetic cardiomyopathy by inhibiting UNC-51-like kinase 1-mediated mitochondrial autophagy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi Wu, Wei-Yi Wang, Jing-Qi Zhang, Sai Wang, Zhi Zeng, Lu Fu and Bin Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Health and Wellness Science and Technology Project of Hubei Province |
WJ2025Q012 |
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| Corresponding Author |
Bin Li, Academic Fellow, Associate Chief Physician, The Clinical Research Center for Acute Myocardial Infarction of Hubei Province, Xianning Central Hospital, No. 228 Jingui Road, Xianning 437000, Hubei Province, China. lbxnszxyy0405@163.com |
| Key Words |
Microtubule affinity-regulating kinase 4; Diabetic cardiomyopathy; Mitochondrial autophagy; UNC-51-like kinase 1; Microtubule-associated protein 1 light chain 3B |
| Core Tip |
This study explored the role of microtubule affinity-regulating kinase 4 (MARK4) in diabetic cardiomyopathy (DCM). The results showed that the MARK4 level was significantly elevated in DCM mice. Down-regulation of MARK4 could alleviate myocardial injury and enhance mitochondrial autophagy function. By up-regulating UNC-51-like kinase 1, the down-regulation of MARK4 promotes mitochondrial autophagy and protects cardiac function. This study reveals the significance of MARK4 as a potential therapeutic target for DCM, providing new ideas for protecting the myocardium of diabetic patients. |
| Publish Date |
2026-01-14 08:09 |
| Citation |
Wu Y, Wang WY, Zhang JQ, Wang S, Zeng Z, Fu L, Li B. Microtubule affinity-regulating kinase 4 exacerbates diabetic cardiomyopathy by inhibiting UNC-51-like kinase 1-mediated mitochondrial autophagy. World J Diabetes 2026; 17(1): 112027 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i1/112027.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i1.112027 |
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