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Articles Published Processes
12/23/2025 8:03:26 AM | Browse: 3 | Download: 10
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Received |
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2025-07-17 03:33 |
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Peer-Review Started |
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2025-07-17 03:34 |
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First Decision by Editorial Office Director |
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2025-08-08 08:58 |
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Return for Revision |
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2025-08-08 08:58 |
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Revised |
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2025-08-18 13:36 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-20 23:18 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-21 01:12 |
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Articles in Press |
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2025-11-21 01:12 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-16 01:49 |
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Publish the Manuscript Online |
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2025-12-23 08:03 |
| ISSN |
2220-6124 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Gut microbiota-derived trimethylamine N-oxide exacerbates diabetic nephropathy by promoting renal fibrosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yue-Juan Song, Bo Yang, Qiang-Sheng Feng, Fei-Fei Ma, Bang Xing, Xi-Liang Bin and Xiao-Qin Ha |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chinese People’s Liberation Army |
No. 2021yxky056 |
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| Corresponding Author |
Xiao-Qin Ha, Chief Physician, Clinical Laboratory, The 940th Hospital of Joint Logistics Support Force of People’s Liberation Army, No. 333 Binhe Middle Road, Lanzhou 730050, Gansu Province, China. songyuejuan410@163.com |
| Key Words |
Diabetic nephropathy; Gut microbiota; Trimethylamine N-oxide; Kidney injury; Fibrosis |
| Core Tip |
Diabetic nephropathy (DN) is characterized by significant renal dysfunction and gut microbiota dysbiosis, which enhances the microbiota’s capacity to produce trimethylamine N-oxide (TMAO). In Zucker diabetic fatty rats, elevated TMAO levels were associated with aggravated renal injury, fibrosis, and upregulated P-smad3 expression. Fecal microbiota transplantation from DN rats further increased TMAO production, confirming TMAO as a key microbiota-derived mediator in DN progression. |
| Publish Date |
2025-12-23 08:03 |
| Citation |
Song YJ, Yang B, Feng QS, Ma FF, Xing B, Bin XL, Ha XQ. Gut microbiota-derived trimethylamine N-oxide exacerbates diabetic nephropathy by promoting renal fibrosis. World J Nephrol 2025; 14(4): 112066 |
| URL |
https://www.wjgnet.com/2220-6124/full/v14/i4/112066.htm |
| DOI |
https://dx.doi.org/10.5527/wjn.v14.i4.112066 |
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