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Articles Published Processes
12/23/2025 8:03:23 AM | Browse: 43 | Download: 127
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Received |
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2025-07-17 02:47 |
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Peer-Review Started |
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2025-07-17 02:49 |
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First Decision by Editorial Office Director |
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2025-08-06 11:25 |
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Return for Revision |
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2025-08-06 11:25 |
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Revised |
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2025-08-08 13:23 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-03 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-04 01:24 |
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Articles in Press |
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2025-11-04 01:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-16 00:21 |
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Publish the Manuscript Online |
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2025-12-23 08:03 |
| ISSN |
2220-6124 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Prognostic value of the MEST-C score in long-term outcomes of immunoglobulin A nephropathy patients: Insights from a developing country
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tabassum Elahi, Saima Ahmed and Muhammed Mubarak |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Muhammed Mubarak, Department of Histopathology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drmubaraksiut@yahoo.com |
| Key Words |
Estimated glomerular filtration rate; End-stage kidney disease; Immunoglobulin A nephropathy; Kidney replacement therapy; MEST-C |
| Core Tip |
This study highlights the prognostic significance of the Oxford MEST-C score classification in immunoglobulin A nephropathy patients in Pakistan. Among 118 biopsy-confirmed cases, higher MEST-C scores - particularly E1, T1/2, and C1/C2 lesions - correlated with worse clinical parameters like proteinuria and estimated glomerular filtration rate, and predicted poor kidney survival. Remission rates declined, and end-stage kidney disease rates increased over time, with only 33.3% kidney survival at 10 years. These findings emphasize the value of integrating histopathological scoring with clinical data for early risk stratification. Delayed diagnosis contributed to adverse outcomes, underscoring the need for timely recognition and intervention in immunoglobulin A nephropathy management. |
| Publish Date |
2025-12-23 08:03 |
| Citation |
Elahi T, Ahmed S, Mubarak M. Prognostic value of the MEST-C score in long-term outcomes of immunoglobulin A nephropathy patients: Insights from a developing country. World J Nephrol 2025; 14(4): 112082 |
| URL |
https://www.wjgnet.com/2220-6124/full/v14/i4/112082.htm |
| DOI |
https://dx.doi.org/10.5527/wjn.v14.i4.112082 |
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