Publication Name	World Journal of Gastroenterology
Manuscript ID	1121
Country	China

Received	2012-11-13 00:39
Peer-Review Started	2012-11-13 19:36
To Make the First Decision	2013-03-04 13:46
Return for Revision	2013-03-07 17:00
Revised	2013-03-14 13:17
Second Decision	2013-03-26 18:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-03-27 13:07
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-04-27 15:44
Publish the Manuscript Online	2013-05-14 16:05

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Increased CD163 expression is associated with acute-on-chronic hepatitis B liver failure
Manuscript Source	Invited Manuscript
All Author List	Hong Ye, Li-Yuan Wang, Jing Zhao and Kai Wang
Funding Agency and Grant Number	Funding Agency Grant Number Key Project of Chinese Ministry of Science and Technology 2012ZX10002007 Key Project of Chinese Ministry of Science and Technology 2013ZX10002001 National Natural Science Foundation of China 81171579 National Natural Science Foundation of China 81201287 Natural Science Foundation of Shandong Province, China ZR2010HM070 Natural Science Foundation of Shandong Province, China ZR2010HQ040
Corresponding Author	Dr. Kai Wang, Department of Hepatology, Qilu Hospital of Shandong University, Wenhuaxi Road 107#, Jinan 250012, Shandong Province, China. wangdoc876@126.com
Key Words	Acute-on-chronic hepatitis B liver failure; Model for end-stage liver disease; CD163; Soluble CD163; Real-time transcription-polymerase chain reaction
Core Tip	This study included three groups, acute-on-chronic hepatitis B liver failure (ACHBLF) patients, chronic hepatitis B (CHB) patients and healthy controls. Flow cytometry was used to analyze the frequency of CD163+ peripheral blood mononuclear cells (PBMCs) and surface protein expression of CD163. Real-time transcription-polymerase chain reaction was performed to assess relative CD163 mRNA levels in PBMCs. The population of CD163+ PBMCs was significantly larger in ACHBLF patients than in CHB patients and healthy controls. CD163 mRNA expression in ACHBLF patients was significantly increased compared with healthy controls. Plasma soluble CD163 (sCD163) levels were markedly increased and correlated with disease severity and prognosis in ACHBLF patients. CD163 and sCD163 may be useful biomarkers for ACHBLF.
Publish Date	2013-05-14 16:05
Citation	Ye H, Wang LY, Zhao J, Wang K. Increased CD163 expression is associated with acute-on-chronic hepatitis B liver failure. World J Gastroenterol 2013; 19(18): 2818-2825
URL	http://www.wjgnet.com/1007-9327/full/v19/i18/2818.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i18.2818

Full Article (PDF)	WJG-19-2818.pdf
Manuscript File	1121-Review.doc
Answering Reviewers	1121-Answering reviewers.pdf
Copyright License Agreement	1121-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	1121-Language certificate.pdf
Peer-review Report	1121-Peer review.pdf
Scientific Editor Work List	1121-Scientific editor work list.doc