BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
12/25/2025 3:52:08 AM | Browse: 16 | Download: 58
 |
Received |
|
2025-07-18 03:36 |
|
Peer-Review Started |
|
2025-07-18 03:36 |
|
First Decision by Editorial Office Director |
|
2025-08-06 10:13 |
|
Return for Revision |
|
2025-08-06 10:13 |
|
Revised |
|
2025-08-19 08:33 |
|
Publication Fee Transferred |
|
2025-08-21 05:36 |
|
Second Decision by Editor |
|
2025-10-30 22:42 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2025-11-06 09:27 |
|
Articles in Press |
|
2025-11-06 09:27 |
|
Edit the Manuscript by Language Editor |
|
2025-11-13 00:52 |
|
Typeset the Manuscript |
|
2025-12-17 08:55 |
|
Publish the Manuscript Online |
|
2025-12-25 03:52 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Human umbilical cord mesenchymal stem cells alleviated diarrhea-type irritable bowel syndrome by improving intestinal function
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
He-Ming Zhang, Yu Zhang, Guang-Jie Luo, An-Xing Zhang, Ruo-Chang Li, Hai-Bo Dong, Teng-Yun Dong, Peng-Cheng Yu, Ying An and Yan Li |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Yan Li, PhD, Professor, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Xishan District, Kunming 650032, Yunnan Province, China. hepatocellular@sina.com |
| Key Words |
Diarrhea-type irritable bowel syndrome; Human umbilical cord mesenchymal stem cells; Gut flora; Intestinal barrier function; Intestinal inflammation |
| Core Tip |
Irritable bowel syndrome (IBS) is a complex bowel disorder marked by recurrent abdominal pain and irregular stools. It is a persistent condition and greatly affects patients’ quality of life. We used three different dosages of human umbilical cord mesenchymal stem cells to treat diarrheal IBS using a rat model. We performed a series of experimental tests and data analyses and found that human umbilical cord mesenchymal stem cells could reduce the expression of inflammatory factors, improve that of intestinal barrier functional proteins, and maintain the abundance and diversity of intestinal flora to restore the intestinal function of diarrheal IBS by colonizing the colon tissue. |
| Publish Date |
2025-12-25 03:52 |
| Citation |
Zhang HM, Zhang Y, Luo GJ, Zhang AX, Li RC, Dong HB, Dong TY, Yu PC, An Y, Li Y. Human umbilical cord mesenchymal stem cells alleviated diarrhea-type irritable bowel syndrome by improving intestinal function. World J Stem Cells 2025; 17(12): 112100 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i12/112100.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i12.112100 |
© 2004-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
