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11/25/2025 11:05:33 AM | Browse: 3 | Download: 12
Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 112124
Country China
Received
2025-07-18 03:51
Peer-Review Started
2025-07-18 03:51
First Decision by Editorial Office Director
2025-08-06 10:09
Return for Revision
2025-08-06 10:09
Revised
2025-08-08 13:12
Publication Fee Transferred
Second Decision by Editor
2025-09-17 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-09-17 03:35
Articles in Press
2025-09-17 03:35
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-11-17 02:30
Publish the Manuscript Online
2025-11-25 11:05
ISSN 1948-9366 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Letter to the Editor
Article Title Concerns regarding lipid metabolism, immune regulation, and methodology in a study on esophageal cancer lymph node metastasis
Manuscript Source Invited Manuscript
All Author List Xu Cui and Zheng Liang
ORCID
Author(s) ORCID Number
Xu Cui http://orcid.org/0000-0003-3346-690X
Funding Agency and Grant Number
Funding Agency Grant Number
Fujian Provincial Science and Technology Innovation Joint Fund Project 2024Y9555
Fujian Provincial Natural Science Foundation Project 2024J011124
Corresponding Author Xu Cui, PhD, Department of Pediatric Surgery, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, No. 18 Daoshan Road, Fuzhou 350001, Fujian Province, China. 16802937@qq.com
Key Words Lipid metabolism; Esophageal cancer; Lymph node metastasis; Low-density lipoprotein; Immune regulation
Core Tip This letter raises concerns about a study investigating lipid metabolism and lymph node metastasis in esophageal cancer, focusing on three key issues: Insufficient data on lipid parameters [especially low-density lipoprotein (LDL) distribution] in the patient cohort, unclear rationale for selecting LDL-related genes and excluding other lipid metabolism pathways in gene screening, and a lack of direct evidence supporting the proposed LDL-B lymphocyte regulatory axis. It emphasizes the complexity of lipid-immune crosstalk in tumors and suggests future studies address these points to strengthen conclusions on lipid-immune regulation in esophageal cancer.
Publish Date 2025-11-25 11:05
Citation

Cui X, Liang Z. Concerns regarding lipid metabolism, immune regulation, and methodology in a study on esophageal cancer lymph node metastasis. World J Gastrointest Surg 2025; 17(11): 112124

URL https://www.wjgnet.com/1948-9366/full/v17/i11/112124.htm
DOI https://dx.doi.org/10.4240/wjgs.v17.i11.112124
Full Article (PDF) WJGS-17-112124-with-cover.pdf
Manuscript File 112124_Auto_Edited_093518.docx
Answering Reviewers 112124-answering-reviewers.pdf
Audio Core Tip 112124-audio.MP3
Conflict-of-Interest Disclosure Form 112124-conflict-of-interest-statement.pdf
Copyright License Agreement 112124-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 112124-non-native-speakers.pdf
Supplementary Material 112124-supplementary-material.pdf
Peer-review Report 112124-peer-reviews.pdf
Scientific Misconduct Check 112124-scientific-misconduct-check.png
Scientific Editor Work List 112124-scientific-editor-work-list.pdf
CrossCheck Report 112124-crosscheck-report.pdf