| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Association of FADS2 polymorphism rs174538 with fatty acid metabolism and disease severity in Japanese patients with Crohn's disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hideyuki Matsuzawa, Zensho Ito, Kan Uchiyama, Yutaro Motoi, Yuichiro Ohtaki, Yuko Iwashita, Shizuka Suzuki, Tatsuya Nakada, Shigeo Koido, Kana Kojima, Kota Murohashi, Masayuki Saruta, Toshifumi Ohkusa and Takahiro Kubota |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hideyuki Matsuzawa, Doctorate Student, Faculty of Pharmacy, Department of Biopharmaceutics, Niigata University of Pharmacy and Medical and Life Sciences, 265-1 Higashijima, Akiha-Ku, Niigata 956-8603, Japan. hideyuki.m.0918@gmail.com |
| Key Words |
Crohn’s disease; FADS2 gene; rs174538; FADS1 gene; Crohn’s disease activity index |
| Core Tip |
Erythrocyte membrane fatty acid composition ratios in Japanese Crohn's disease (CD) patients are distinctive. Analysis was performed to determine effects on FADS2 genetic polymorphisms by serum and erythrocyte membrane fatty acid composition ratios, shown by delta 6 and delta 5 desaturases (D6D and D5D, respectively), and also disease activities. The FADS2 gene with the rs174538 mutation affected D6D and D5D activities, with a greater effect on D5D. However, for disease activity, wild-type rs174538 was positively correlated with D6D activity. These results indicate that confirmation of the rs174538 mutation can be used to predict disease severity in CD cases. |
| Publish Date |
2026-01-12 09:50 |
| Citation |
Matsuzawa H, Ito Z, Uchiyama K, Motoi Y, Ohtaki Y, Iwashita Y, Suzuki S, Nakada T, Koido S, Kojima K, Murohashi K, Saruta M, Ohkusa T, Kubota T. Association of FADS2 polymorphism rs174538 with fatty acid metabolism and disease severity in Japanese patients with Crohn's disease. World J Gastroenterol 2026; 32(2): 112132 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i2/112132.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i2.112132 |
