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Articles Published Processes
5/13/2026 8:18:27 AM | Browse: 2 | Download: 28
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Received |
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2025-07-21 05:16 |
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Peer-Review Started |
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2025-07-21 05:16 |
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First Decision by Editorial Office Director |
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2025-08-06 10:39 |
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Return for Revision |
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2025-08-06 10:39 |
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Revised |
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2025-08-16 19:05 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-24 02:49 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-25 03:31 |
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Articles in Press |
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2025-11-25 03:31 |
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Edit the Manuscript by Language Editor |
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2025-11-30 00:50 |
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Typeset the Manuscript |
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2026-02-25 09:38 |
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Publish the Manuscript Online |
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2026-05-13 08:18 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Case Control Study |
| Article Title |
Role of soluble alpha-klotho as a novel biomarker for characterizing children with autism spectrum disorder in Kurdistan, Iraq
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Thikra A Allwsh and Dezheen S Kucher |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Thikra A Allwsh, PhD, Professor, Department of Chemistry, University of Mosul, Al-Zahour, Mosul 41003, Nineveh, Iraq. thekraaliallwsh@uomosul.edu.iq |
| Key Words |
Klotho; Autism spectrum disorder; Novel biomarker; Kurdistan; Vitamin D; Glucose |
| Core Tip |
This study is the first to examine the relationship between klotho (S-KLα) and autism spectrum disorder (ASD). It involves two groups aged 2-15 years: One healthy group and another comprising patients from autism centres in the Kurdistan Region, Iraq. We compared these groups and analysed risk factors associated with ASD. The results showed a significant reduction in S-KLα levels in the sera of ASD patients. Using the receiver operating characteristic curve, we determined an area under the curve of 0.91, indicating the potential of S-KLα as a marker for ASD. Additionally, S-KLα levels were affected by several risk factors and demonstrated a significant correlation with multiple clinical markers, suggesting a possible role for S-KLα in ASD and its potential as a predictive biomarker in ASD risk assessment. These findings improve understanding of the pathophysiological mechanisms and provide new insights. |
| Publish Date |
2026-05-13 08:18 |
| Citation |
Allwsh TA, Kucher DS. Role of soluble alpha-klotho as a novel biomarker for characterizing children with autism spectrum disorder in Kurdistan, Iraq. World J Clin Pediatr 2026; 15(2): 112164 |
| URL |
https://www.wjgnet.com/2219-2808/full/v15/i2/112164.htm |
| DOI |
https://dx.doi.org/10.5409/wjcp.v15.i2.112164 |
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