| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Basic Study |
| Article Title |
Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-Feng Zeng, Jin Rao, Xi-Bei Xia, Xiang-Yu Chen, Hong-Xiang He, Bin Liu, Qiong Chen, Yu-Di Liu, Guo-Ji Wang, Peng-Chao Cheng, Jun-Nan Wang, Pei Wang, Yue Yu and Zhi-Nong Wang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zhi-Nong Wang, PhD, Professor, Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, No. 415 Fengyang Road, Huangpu District, Shanghai 200003, China. wangzn007@smmu.edu.cn |
| Key Words |
Mesenchymal stem cells; Hypoxic preconditioning; Exosomes; miR-486-5p; Oxidative stress; Apoptosis |
| Core Tip |
Hypoxic preconditioning enhances the therapeutic properties of mesenchymal stem cell-derived exosomes with elevated miR-486-5p, which directly inhibits phosphatase and tensin homolog to ignite phosphatidylinositol 3-kinase/protein kinase B signaling and thereby halts oxidative stress-driven cardiomyocyte apoptosis. This work uncovers a microRNA-mediated mechanism that endows exosomes with superior cardioprotective potency, offering a cell-free therapeutic strategy for oxidative-related cardiac injury. |
| Publish Date |
2025-12-25 03:52 |
| Citation |
Zeng ZF, Rao J, Xia XB, Chen XY, He HX, Liu B, Chen Q, Liu YD, Wang GJ, Cheng PC, Wang JN, Wang P, Yu Y, Wang ZN. Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p. World J Stem Cells 2025; 17(12): 112207 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i12/112207.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i12.112207 |
