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Articles Published Processes
12/4/2025 6:40:47 AM | Browse: 10 | Download: 27
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Received |
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2025-07-21 01:15 |
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Peer-Review Started |
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2025-07-21 01:16 |
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First Decision by Editorial Office Director |
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2025-07-30 07:55 |
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Return for Revision |
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2025-07-30 07:55 |
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Revised |
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2025-08-03 22:09 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-20 02:57 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-21 01:57 |
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Articles in Press |
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2025-10-21 01:57 |
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Edit the Manuscript by Language Editor |
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2025-10-24 20:49 |
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Typeset the Manuscript |
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2025-12-02 00:59 |
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Publish the Manuscript Online |
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2025-12-04 06:40 |
| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Gut microbiome and chemotherapy-induced cardiotoxicity: A systematic review of evidence and emerging therapies
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Razan Abdulaal, Imad Afara, Ali Harajli, Ehab Al Mashtoub, Alaa Tarchichi, Karim Hassan, Ali Afara, Jana Abou Fakher, Sethrida Salhab, Issam Fassih and Mohamad Tlais |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mohamad Tlais, Department of Cardiology, University of Balamand, Dekweneh, Beirut 1100, Beyrouth, Lebanon. mmtlaiss22@gmail.com |
| Key Words |
Gut microbiome; Chemotherapy-induced cardiotoxicity; Short-chain fatty acids; Trimethylamine-N-oxide; Gut-heart axis; Microbiome-targeted therapies |
| Core Tip |
This systematic review highlights the emerging role of the gut microbiome in chemotherapy-induced cardiotoxicity, focusing on how dysbiosis disrupts microbial metabolite balance, particularly short-chain fatty acids and trimethylamine-N-oxide, to drive inflammation, oxidative stress, and cardiac damage. The review synthesizes mechanistic insights and evaluates microbiome-targeted interventions such as probiotics, prebiotics, and fecal microbiota transplantation. It emphasizes the gut-heart axis as a novel therapeutic target in cardio-oncology and underscores the need for standardized clinical trials to translate these findings into personalized medicine. |
| Publish Date |
2025-12-04 06:40 |
| Citation |
Abdulaal R, Afara I, Harajli A, Al Mashtoub E, Tarchichi A, Hassan K, Afara A, Abou Fakher J, Salhab S, Fassih I, Tlais M. Gut microbiome and chemotherapy-induced cardiotoxicity: A systematic review of evidence and emerging therapies. World J Biol Chem 2025; 16(4): 112221 |
| URL |
https://www.wjgnet.com/1949-8454/full/v16/i4/112221.htm |
| DOI |
https://dx.doi.org/10.4331/wjbc.v16.i4.112221 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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