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Articles Published Processes
10/21/2025 9:08:31 AM | Browse: 2 | Download: 1
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Received |
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2025-07-22 03:37 |
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Peer-Review Started |
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2025-07-22 03:37 |
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To Make the First Decision |
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Return for Revision |
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2025-07-30 08:55 |
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Revised |
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2025-08-03 09:46 |
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Second Decision |
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2025-09-15 02:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-15 03:42 |
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Articles in Press |
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2025-09-15 03:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-15 01:24 |
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Publish the Manuscript Online |
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2025-10-21 09:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Stem cell- and extracellular vesicle-based therapies for perianal fistulizing Crohn’s disease: An updated review
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Payal Bhatnagar, Sherreen Elhariri, Ismail A S Burud and Nabil Eid |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Nabil Eid, Associate Professor, MD, PhD, Department of Human Biology, Anatomy Division, School of Medicine, IMU University, Bukit Jalil, Kuala Lumpur 57000, Malaysia. nabilsaleheid@imu.edu.my |
| Key Words |
Mesenchymal stem cells; Crohn’s disease; Perianal fistulizing Crohn’s disease; Extracellular vesicles; Exosomes; Autophagy |
| Core Tip |
Perianal fistulizing Crohn’s disease (PFCD) is a severe complication of CD, characterized by the accumulation of inflammatory cells and elevated cytokine production. Although various medical and surgical approaches aim to control this disease, recurrence remains a major challenge. Both animal models and clinical trials have shown that mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) can reduce inflammation and promote healing in refractory PFCD effects that may be further enhanced by autophagy activation. This review highlights the therapeutic potential of MSCs and their EVs in PFCD treatment and explores the supportive role of autophagy in enhancing their efficacy. |
| Publish Date |
2025-10-21 09:08 |
| Citation |
<p>Bhatnagar P, Elhariri S, Burud IAS, Eid N. Stem cell- and extracellular vesicle-based therapies for perianal fistulizing Crohn’s disease: An updated review. <i>World J Gastroenterol</i> 2025; 31(39): 112229</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i39/112229.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i39.112229 |
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