| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Androgen receptor mutations in familial androgen insensitivity syndrome: A metabolic reprogramming pathway to type 2 diabetes susceptibility
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Cheng Luo, Wei-Wei Zhang, Liang-Yan Hua, Mei-Qi Zeng, Hui Xu, Cheng-Zheng Duan, Shi-Yu Xu, Shuo Zhan, Xiao-Fei Pan, Da Sun, Li-Ya Ye and Dong-Juan He |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Quzhou Science and Technology Plan Project |
No. 2022K69 |
|
| Corresponding Author |
Dong-Juan He, Chief Physician, Dean, Director, Professor, Department of Endocrinology, The Second People’s Hospital of Quzhou, No. 338 Xin’an Avenue, Qujiang District, Quzhou 324002, Zhejiang Province, China. hedongjuan1247@wmu.edu.cn |
| Key Words |
Androgen insensitivity syndrome; Androgen receptor; Gene mutation; Metabolic reprogramming; Type 2 diabetes |
| Core Tip |
Familial androgen insensitivity syndrome (AIS), caused by androgen receptor gene mutations, has long been viewed as a disorder of sex development. However, recent findings revealed that androgen receptor dysfunction also drives metabolic reprogramming in key tissues - pancreatic β-cells, skeletal muscle, liver, and adipose tissue - leading to insulin resistance and increased susceptibility to type 2 diabetes mellitus. This article highlights emerging evidence of glucagon-like peptide-1 signaling disruption, mitochondrial dysfunction, and inflammatory imbalance in AIS. We propose an integrated framework of genetic screening, endocrine surveillance, and individualized therapy to improve long-term metabolic outcomes and prevent cardiometabolic complications in AIS patients. |
| Publish Date |
2025-11-14 08:23 |
| Citation |
Luo C, Zhang WW, Hua LY, Zeng MQ, Xu H, Duan CZ, Xu SY, Zhan S, Pan XF, Sun D, Ye LY, He DJ. Androgen receptor mutations in familial androgen insensitivity syndrome: A metabolic reprogramming pathway to type 2 diabetes susceptibility. World J Diabetes 2025; 16(11): 112236 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i11/112236.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i11.112236 |
