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Articles Published Processes
1/20/2026 2:54:06 AM | Browse: 66 | Download: 244
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Received |
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2025-07-23 05:30 |
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Peer-Review Started |
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2025-07-23 05:31 |
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First Decision by Editorial Office Director |
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2025-08-14 04:55 |
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Return for Revision |
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2025-08-14 04:55 |
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Revised |
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2025-09-09 02:26 |
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Publication Fee Transferred |
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2025-09-17 01:39 |
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Second Decision by Editor |
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2025-11-21 10:23 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-02 07:56 |
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Articles in Press |
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2025-12-02 07:56 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-12 02:46 |
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Publish the Manuscript Online |
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2026-01-20 02:54 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Basic Study |
| Article Title |
Hypoxia facilitates triple-negative breast cancer stem cells enrichment and stemness maintenance through oxidized ataxia telangiectasia mutated-induced one-carbon metabolism
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dan Yang, Yu-Lian Ou, Shu-Hui Wang, Hong-Jun Jin, Su-Hua Chen, Ran Han and Hua Zhang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ran Han, Outpatient Department, Guizhou Provincial People’s Hospital, No. 83 Zhongshan East Road, Guiyang 550002, Guizhou Province, China. hanran105@sina.com |
| Key Words |
Hypoxia; Oxidized ataxia telangiectasia mutated; Cancer stem cells; Triple-negative breast cancer; One-carbon metabolism; Methylenetetrahydrofolate dehydrogenase 2; Serine hydroxymethyltransferase 2 |
| Core Tip |
This study demonstrates that hypoxia activates oxidized ataxia telangiectasia mutated kinase, which plays a pivotal role in enhancing the stemness of triple-negative breast cancer stem cells. Through c-Myc-mediated transcriptional regulation, hypoxia promotes one-carbon metabolism and significantly upregulates key metabolic enzymes, including methylenetetrahydrofolate dehydrogenase 2 and serine hydroxymethyltransferase 2. These metabolic adaptations support redox balance and self-renewal capacity, highlighting a potential therapeutic axis targeting oxidized ataxia telangiectasia mutated-driven metabolic reprogramming in triple-negative breast cancer. |
| Publish Date |
2026-01-20 02:54 |
| Citation |
Yang D, Ou YL, Wang SH, Jin HJ, Chen SH, Han R, Zhang H. Hypoxia facilitates triple-negative breast cancer stem cells enrichment and stemness maintenance through oxidized ataxia telangiectasia mutated-induced one-carbon metabolism. World J Stem Cells 2026; 18(1): 112278 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i1/112278.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i1.112278 |
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