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Publication Name World Journal of Clinical Cases
Manuscript ID 112305
Country China
Received
2025-07-29 01:05
Peer-Review Started
2025-07-29 01:05
To Make the First Decision
Return for Revision
2025-08-20 07:51
Revised
2025-09-03 02:51
Second Decision
2025-10-23 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-10-23 06:55
Articles in Press
2025-10-23 06:55
Publication Fee Transferred
2025-09-08 07:54
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-11-14 01:55
Publish the Manuscript Online
2025-11-21 03:54
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Case Report
Article Title Recurrent hemoptysis after laryngectomy-acquired hemophilia induced by laryngeal cancer surgery and chemoradiotherapy: A case report
Manuscript Source Unsolicited Manuscript
All Author List Peng-Wei Zhao, Yan-Sheng Hu, Zheng Jiang, Mailudan Ainiwaer, Jun Liu and Fei Chen
ORCID
Author(s) ORCID Number
Yan-Sheng Hu http://orcid.org/0009-0000-5235-2225
Jun Liu http://orcid.org/0000-0003-4800-7749
Fei Chen http://orcid.org/0000-0003-2152-368X
Funding Agency and Grant Number
Corresponding Author Fei Chen, Associate Professor, MD, PhD, Department of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Guo xue xiang No.37, Chengdu 610048, Sichuan Province, China. hxchenfei@163.com
Key Words Acquired hemophilia A; Hypopharyngeal squamous Cell carcinoma; Surgery; Chemoradiotherapy; Paraneoplastic Syndrome; Immunosuppressive therapy; Case report
Core Tip We report a unique case of acquired hemophilia A, an autoimmune bleeding disorder due to factor VIII (FVIII) autoantibodies, occurring after head and neck cancer surgery and chemoradiotherapy—a previously unreported association. A 65-year-old male developed recurrent hemoptysis, diagnosed by prolonged activated partial thromboplastin time and high-titer FVIII inhibitors. Intensive immunosuppressive therapy achieved sustained six-year remission, demonstrating the critical role of timely diagnosis and aggressive management for this severe therapy-related complication.
Publish Date 2025-11-21 03:54
Citation <p>Zhao PW, Hu YS, Jiang Z, Ainiwaer M, Liu J, Chen F. Recurrent hemoptysis after laryngectomy-acquired hemophilia induced by laryngeal cancer surgery and chemoradiotherapy: A case report. <i>World J Clin Cases</i> 2025; 13(33): 112305</p>
URL https://www.wjgnet.com/2307-8960/full/v13/i33/112305.htm
DOI https://dx.doi.org/10.12998/wjcc.v13.i33.112305
Full Article (PDF) WJCC-13-112305-with-cover.pdf
CARE Checklist–2016 112305-CARE-Checklist-2016.pdf
Manuscript File 112305_Auto_Edited_034625.docx
Answering Reviewers 112305-answering-reviewers.pdf
Audio Core Tip 112305-audio.mp3
Conflict-of-Interest Disclosure Form 112305-conflict-of-interest-statement.pdf
Copyright License Agreement 112305-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s) 112305-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate 112305-non-native-speakers.pdf
Peer-review Report 112305-peer-reviews.pdf
Scientific Misconduct Check 112305-scientific-misconduct-check.png
Scientific Editor Work List 112305-scientific-editor-work-list.pdf
CrossCheck Report 112305-crosscheck-report.pdf