| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Transient elastography and fibrosis-4 index as predictors of hepatocellular carcinoma in hepatitis C virus patients with sustained virological response
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Paula G F da Silva, Juliana B P Barrocas, Hugo Perazzo, Livia Villela-Nogueira, Helena R Peixoto, Gustavo H S Pereira, Lailiane N P Braga, Miriam Chinzon, Joyce R L de Silva, Flávia F Fernandes and Cristiane A Villela-Nogueira |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Cristiane A Villela-Nogueira, Full Professor, MD, PhD, School of Medicine, Department of Internal Medicine, Federal University of Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, 255 room 9E16 Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21941617, Brazil. crisvillelanog@gmail.com |
| Key Words |
Hepatocellular carcinoma; Sustained virological response; Hepatitis C virus; Liver stiffness; Noninvasive tests; Fibrosis-4 index score |
| Core Tip |
This retrospective longitudinal study was conducted in two tertiary centers to evaluate noninvasive tests as predictive factors for developing hepatocellular carcinoma (HCC). The cohort included people with chronic hepatitis C virus infection and compensated advanced chronic liver disease, defined as pre-treatment liver stiffness measurement (LSM) ≥ 10 kPa, who achieved sustained virological response after direct-acting antivirals therapy. At pre-treatment and 1-year end of treatment, fibrosis-4 index score ≥ 3.25 and LSM ≥ 20 kPa were independently associated with the incidence of HCC. |
| Publish Date |
2025-12-03 09:10 |
| Citation |
da Silva PGF, Barrocas JBP, Perazzo H, Villela-Nogueira L, Peixoto HR, Pereira GHS, Braga LNP, Chinzon M, de Silva JRL, Fernandes FF, Villela-Nogueira CA. Transient elastography and fibrosis-4 index as predictors of hepatocellular carcinoma in hepatitis C virus patients with sustained virological response. World J Gastroenterol 2025; 31(45): 112318 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i45/112318.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i45.112318 |
