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Articles Published Processes
1/15/2026 8:12:52 AM | Browse: 45 | Download: 193
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Received |
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2025-07-24 08:11 |
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Peer-Review Started |
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2025-07-24 08:12 |
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First Decision by Editorial Office Director |
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2025-08-20 07:34 |
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Return for Revision |
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2025-08-20 07:34 |
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Revised |
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2025-09-24 09:12 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-08 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-08 11:14 |
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Articles in Press |
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2025-12-08 11:14 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-06 05:44 |
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Publish the Manuscript Online |
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2026-01-15 08:12 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Fixed vs weight-based heparin dosing in stable patients undergoing diagnostic coronary physiology studies
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kristoffer Ken Ralota, Deniz Tuncer, Nay Min Htun, Rohit Samuel, Vivek Gupta, Robert Lew and Jamie Layland |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jamie Layland, Consultant, FRACP, MD, MRCP, PhD, Professor, Senior Researcher, Department of Medicine, Peninsula Health, Monash University, 2 Hastings Road, Frankston, Melbourne, Frankston 3199, Victoria, Australia. jlayland@phcn.vic.gov.au |
| Key Words |
Unfractionated heparin; Coronary physiology; Fractional flow reserve; Microvascular function; Anticoagulation; Fixed-dose heparin; Heparin dose; Pressure-wire |
| Core Tip |
This study explores the safety and efficacy of fixed-dose vs weight-based unfractionated heparin dosing during diagnostic coronary physiology procedures. Among 128 patients, fixed-dose 5000 IU unfractionated heparin was associated with similarly low rates of bleeding and no thrombotic events compared to weight-based dosing. These findings suggest that a fixed-dose approach may be a safe and practical alternative in low-risk, physiology-only settings. The results may inform future research and support consideration of simplified anticoagulation strategies in stable patients undergoing diagnostic coronary physiology assessments. |
| Publish Date |
2026-01-15 08:12 |
| Citation |
Ralota KK, Tuncer D, Htun NM, Samuel R, Gupta V, Lew R, Layland J. Fixed vs weight-based heparin dosing in stable patients undergoing diagnostic coronary physiology studies. World J Cardiol 2026; 18(1): 112321
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| URL |
https://www.wjgnet.com/1949-8462/full/v18/i1/112321.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v18.i1.112321 |
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