| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Control Study |
| Article Title |
Single-nucleotide variants in microRNAs associated with breast cancer in women from western Mexico
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Marcelo Victorio-De Los Santos, Andrés A Rodríguez-López, Jorge Gutiérrez-Franco, Amelia Rodríguez-Trejo, Zulia F Nieves-López, Rafael Torres-Valadez, Eloy A Zepeda-Carrillo, Marco F Flores-Reyes, Miriam F Ayón-Pérez and Alejandro Vázquez-Reyes |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Patronage fo the Autonomous University of Nayarit, Quality Postgraduate Program with resources from the 15% Special Tax allocated to the UAN 2022 |
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| Corresponding Author |
Alejandro Vázquez-Reyes, PhD, Professor, Laboratorios de Investigación en Biología Molecular e Inmunología, Universidad Autónoma de Nayarit, Ciudad de la Cultura Amado Nervo S/N, Tepic 63000, Nayarit, Mexico. avazquez@uan.edu.mx |
| Key Words |
Breast cancer; MicroRNAs; Genetic variants; Single-nucleotide variant; Women |
| Core Tip |
Breast cancer (BrC) is a complex disease influenced by both environmental and genetic factors. Among the latter, acquired or inherited single-nucleotide variants can increase the risk of developing BrC by up to 50%. single-nucleotide variants in microRNAs may alter their function or biogenesis, potentially contributing to oncogenesis. This study aimed to analyze the association of rs11614913 in MIR196A2, rs2682818 in MIR618, and rs73262897 in the regulatory region of MIR200C with the risk of developing BrC in women from western Mexico. The variants rs11614913 and rs2682818 showed a protective effect against BrC in this population. |
| Publish Date |
2025-11-21 07:06 |
| Citation |
<p>Victorio-De Los Santos M, Rodríguez-López AA, Gutiérrez-Franco J, Rodríguez-Trejo A, Nieves-López ZF, Torres-Valadez R, Zepeda-Carrillo EA, Flores-Reyes MF, Ayón-Pérez MF, Vázquez-Reyes A. Single-nucleotide variants in microRNAs associated with breast cancer in women from western Mexico. <i>World J Clin Oncol</i> 2025; 16(11): 112349</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i11/112349.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i11.112349 |
