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11/13/2025 6:51:08 AM | Browse: 11 | Download: 74
Publication Name World Journal of Gastroenterology
Manuscript ID 112354
Country China
Received
2025-07-25 14:36
Peer-Review Started
2025-07-25 14:36
First Decision by Editorial Office Director
2025-08-07 09:44
Return for Revision
2025-08-07 09:44
Revised
2025-08-18 14:10
Publication Fee Transferred
2025-08-21 01:49
Second Decision by Editor
2025-10-13 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-10-13 06:40
Articles in Press
2025-10-13 06:40
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-10-30 09:35
Publish the Manuscript Online
2025-11-13 06:51
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, General & Internal
Manuscript Type Retrospective Cohort Study
Article Title Development and validation of a predictive model for portal-systemic venous invasion grading in borderline resectable pancreatic cancer
Manuscript Source Unsolicited Manuscript
All Author List Fang-Fei Wang, Xiao-Di Dai, Xin Zhao, Qiang He and Shao-Cheng Lyu
ORCID
Author(s) ORCID Number
Fang-Fei Wang http://orcid.org/0000-0002-5752-3828
Xin Zhao http://orcid.org/0000-0001-9585-8306
Qiang He http://orcid.org/0000-0002-5007-5225
Shao-Cheng Lyu http://orcid.org/0000-0002-2757-7868
Funding Agency and Grant Number
Corresponding Author Shao-Cheng Lyu, Department of Hepatobiliary Pancreas and Spleen Surgery, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing 100020, China. shaocheng0502@163.com
Key Words Borderline resectable pancreatic cancer; Portosystemic venous invasion; Pathological grading; Predictive model; Adventitial invasion; Muscularis propria invasion; Intimal invasion
Core Tip This study developed a predictive model for pathological grading of portosystemic venous invasion depth in borderline resectable pancreatic cancer using routine preoperative indicators: Serum carbohydrate antigen 19-9, computed tomography circumferential involvement angle, and luminal compromise. The model achieved high accuracy (C-index 0.928) in stratifying venous invasion depth into adventitial, muscularis propria, or intimal invasion, which significantly affected prognosis (e.g., intimal invasion showed worst median overall survival of 9 months). This innovative tool enables preoperative risk quantification, guiding personalized therapy decisions such as neoadjuvant intensification or surgical planning, and addresses a critical unmet need in precision oncology for borderline resectable pancreatic cancer.
Publish Date 2025-11-13 06:51
Citation

Wang FF, Dai XD, Zhao X, He Q, Lyu SC. Development and validation of a predictive model for portal-systemic venous invasion grading in borderline resectable pancreatic cancer. World J Gastroenterol 2025; 31(42): 112354

URL https://www.wjgnet.com/1007-9327/full/v31/i42/112354.htm
DOI https://dx.doi.org/10.3748/wjg.v31.i42.112354
Full Article (PDF) WJG-31-112354-with-cover.pdf
STROBE Statement 112354-STROBE-statement.pdf
Manuscript File 112354_Auto_Edited_075838.docx
Answering Reviewers 112354-answering-reviewers.pdf
Audio Core Tip 112354-audio.mp3
Biostatistics Review Certificate 112354-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 112354-conflict-of-interest-statement.pdf
Copyright License Agreement 112354-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 112354-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 112354-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 112354-non-native-speakers.pdf
Supplementary Material 112354-supplementary-material.pdf
Peer-review Report 112354-peer-reviews.pdf
Scientific Misconduct Check 112354-scientific-misconduct-check.png
Scientific Editor Work List 112354-scientific-editor-work-list.pdf
CrossCheck Report 112354-crosscheck-report.pdf