| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Dachengqitang mitigates endoscopic retrograde cholangiopancreatography-induced pancreatitis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lei Zheng, Jin Wang, Mao-Qi Xu, Wen Jiang, Long Qian, Yu Ge, Mao-Kun Feng, Yi-Mei Zhu, Meng-Jun Wang, Sha-Sha Sun, Chang-Kuo Liu, Xiao-Ming Wang and Chao Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Research Project of Higher Education Institution of Anhui Provincial Department of Education |
2022AH052638 and 2023AH040254 |
|
| Corresponding Author |
Xiao-Ming Wang, The Fifth Clinical Medical College, Anhui Medical University, No. 240 Jiuhua Middle Road, Jinghu District, Wuhu 230032, Anhui Province, China. wxm6901@126.com |
| Key Words |
Dachengqitang; Post-ERCP acute pancreatitis; Postoperative complications; Intestinal mucosal barrier; M1 macrophages; Inflammation |
| Core Tip |
Post-ERCP acute pancreatitis is a serious complication involving intestinal mucosal barrier dysfunction and excessive inflammation. This study integrates bioinformatics analysis with in vivo and in vitro models to investigate the protective effects of Dachengqitang (DCQT). The results demonstrate that DCQT enhances intestinal barrier integrity by upregulating ZO-1 and Occludin-1, reduces M1 macrophage activation, and promotes M2 polarization with increased IL-10 expression. DCQT also improves mitochondrial membrane potential in epithelial cells. These findings highlight the therapeutic potential of DCQT in managing postoperative inflammatory responses following ERCP. |
| Publish Date |
2026-03-27 12:16 |
| Citation |
Zheng L, Wang J, Xu MQ, Jiang W, Qian L, Ge Y, Feng MK, Zhu YM, Wang MJ, Sun SS, Liu CK, Wang XM, Zhang C. Dachengqitang mitigates endoscopic retrograde cholangiopancreatography-induced pancreatitis. World J Gastrointest Surg 2026; 18(3): 112405 |
| URL |
https://www.wjgnet.com/1948-9366/full/v18/i3/112405.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v18.i3.112405 |
