| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Tail clamping induces anxiety-like behaviors and visceral hypersensitivity in rat models of non-erosive reflux disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Mi Lv, Xin Liu, Kai-Yue Huang, Yu-Xi Wang, Zheng Wang, Li-Li Han, Hui Che, Lin Lv and Feng-Yun Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Key Specialty of Traditional Chinese Medicine (Spleen and Stomach Diseases) |
0500004 |
| National Natural Science Foundation of China |
82205104 |
| National Natural Science Foundation of China |
82104850 |
| Hospital Capability Enhancement Project of Xiyuan Hospital, CACMS |
XYZX0303-07 |
| the Fundamental Research Funds for the Central Public Welfare Research Institutes, Excellent Young Scientists Training Program of China Academy of Chinese Medical Sciences |
ZZ16-YQ-002 |
|
| Corresponding Author |
Feng-Yun Wang, Chief Physician, MD, Professor, Institute of Digestive Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, No.1 Xiyuan Playground, Haidian District, Beijing, China, Beijing 100091, China. 18810631761@163.com |
| Key Words |
Non-erosive reflux disease; Anxiety and depression; Animal model; Tail-clamping; Corticotropin hormones |
| Core Tip |
This study systematically compares two non-surgical modeling approaches, ovalbumin (OVA)/aluminum hydroxide suspension [Al(OH)3] + acid perfusion vs fructose water + tail clamping, for non-erosive reflux disease (NERD). It demonstrates that a 7-day tail clamping protocol effectively induces anxiety-like behaviors and exacerbates visceral hypersensitivity through corticotropin-releasing hormone-mediated neuroimmune pathways. The modified OVA/Al(OH)3 model combined with tail clamping establishes an efficient platform for investigating brain-gut interactions in NERD with psychiatric comorbidity. This novel approach offers significant advantages over traditional chronic stress methods in terms of both induction efficiency (requiring only 40 minutes/day for 7 days) and pathological reproducibility. |
| Publish Date |
2025-12-31 05:47 |
| Citation |
Lv M, Liu X, Huang KY, Wang YX, Wang Z, Han LL, Che H, Lv L, Wang FY. Tail clamping induces anxiety-like behaviors and visceral hypersensitivity in rat models of non-erosive reflux disease. World J Psychiatry 2026; 16(1): 112432 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i1/112432.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i1.112432 |
