| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Interplay between viral infections and gut microbiota dysbiosis: Mechanisms and therapeutic potential
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Tsvetelina Velikova, Hassan Ali, Hristiana Batselova, Lyubomir Chervenkov, Dimitrina Miteva, Milena Peruhova, Milena Gulinac, Latchezar Tomov, Yordanka Mitova-Mineva and Valeri Velev |
| ORCID |
|
| Funding Agency and Grant Number |
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| Corresponding Author |
Valeri Velev, Associate Professor, DM, MD, PhD, Department of Infectious Diseases and Parasitology, Medical University of Sofia, 2 Zdrave Street, Sofia 1431, Bulgaria. velev_md@abv.bg |
| Key Words |
Viral infection; SARS-CoV-2; COVID-19; Human immunodeficiency virus; Influenza; Hepatitis viruses; Gut microbiota; Dysbiosis; Probiotics; Fecal microbiota transplantation |
| Core Tip |
Viral infections, including those caused by emerging pathogens like severe acute respiratory syndrome coronavirus 2, can profoundly disrupt the gut microbiota, leading to dysbiosis that contributes to immune dysregulation, heightened inflammation, and worsened clinical outcomes. These microbiota alterations can influence disease severity, increase susceptibility to secondary infections, and affect the metabolism of medications. Understanding the gut-virus-immune system interplay is essential for developing effective strategies to restore microbial balance. Microbiota-targeted therapies such as probiotics, prebiotics, and fecal microbiota transplantation offer promising options for managing dysbiosis in the context of viral infectious diseases. |
| Publish Date |
2026-01-16 11:31 |
| Citation |
Velikova T, Ali H, Batselova H, Chervenkov L, Miteva D, Peruhova M, Gulinac M, Tomov L, Mitova-Mineva Y, Velev V. Interplay between viral infections and gut microbiota dysbiosis: Mechanisms and therapeutic potential. World J Gastroenterol 2026; 32(3): 112437 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i3/112437.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i3.112437 |
