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Articles Published Processes
11/26/2025 3:57:03 AM | Browse: 28 | Download: 77
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Received |
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2025-07-28 14:29 |
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Peer-Review Started |
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2025-07-28 14:30 |
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First Decision by Editorial Office Director |
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2025-09-04 07:16 |
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Return for Revision |
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2025-09-04 07:16 |
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Revised |
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2025-09-16 09:12 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-20 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-20 10:37 |
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Articles in Press |
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2025-10-20 10:37 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-31 13:22 |
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Publish the Manuscript Online |
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2025-11-26 03:57 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Insights into mitofusin-2 and endoplasmic reticulum stress regulation in adipose-derived mesenchymal stem cells senescence
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fang Lin, Ke-Xin Ma and Xiao-Ting Liang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shenzhen Science and Technology Program |
JCYJ20240813162036046 |
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| Corresponding Author |
Xiao-Ting Liang, MD, PhD, Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai 200120, China. liangxt@tongji.edu.cn |
| Key Words |
Adipose-derived mesenchymal stem cells; Senescence; Endoplasmic reticulum stress; Nuclear factor erythroid-derived 2; Mitofusin-2 |
| Core Tip |
Fang’s study links the nuclear factor erythroid-derived 2-mitofusin-2 (MFN2) axis to endoplasmic reticulum stress and senescence in adipose-derived mesenchymal stem cells from obese mice. While the evidence for reduced nuclear factor erythroid-derived 2 and MFN2 suppression is compelling, key issues remain. The specific function of MFN2 in aging adipose-derived mesenchymal stem cells, its potential interaction with binding immunoglobulin protein, and its influence on endoplasmic reticulum stress remain unresolved. Future studies should elucidate the role of MFN2, establish direct biochemical evidence, and assess the therapeutic relevance of targeting this axis in insulin resistance using diet-induced obesity models. |
| Publish Date |
2025-11-26 03:57 |
| Citation |
Lin F, Ma KX, Liang XT. Insights into mitofusin-2 and endoplasmic reticulum stress regulation in adipose-derived mesenchymal stem cells senescence. World J Stem Cells 2025; 17(11): 112476 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i11/112476.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i11.112476 |
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