Publication Name	World Journal of Gastroenterology
Manuscript ID	112483
Country	China

Received	2025-07-29 05:04
Peer-Review Started	2025-07-29 05:05
To Make the First Decision
Return for Revision	2025-08-19 10:13
Revised	2025-09-02 03:07
Second Decision	2025-10-13 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-13 06:16
Articles in Press	2025-10-13 06:16
Publication Fee Transferred	2025-09-08 15:24
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-11-07 08:35
Publish the Manuscript Online	2025-11-20 07:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Distal small bowel resection with preservation of the terminal ileum suppresses hepatic gluconeogenesis via the Prevotellaceae_NK3B31_group-mediated 7-KLCA-FXR axis
Manuscript Source	Unsolicited Manuscript
All Author List	Chi-Ying Xu, Zhi-Hua Zheng, Kun Yang, Ren-Ran Wu, Jia-Qing Cao and Jin-Yuan Duan
ORCID	Author(s) ORCID Number Chi-Ying Xu http://orcid.org/0009-0006-2150-762X Zhi-Hua Zheng http://orcid.org/0009-0007-7695-6921 Kun Yang http://orcid.org/0009-0004-1928-4549 Ren-Ran Wu http://orcid.org/0009-0002-4173-6981 Jin-Yuan Duan http://orcid.org/0000-0002-7772-7844
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82360168 and 81960154 Natural Science Foundation of Jiangxi Province 20212BAB206020 Foundation of Health Commission of Jiangxi Province 202310024
Corresponding Author	Jin-Yuan Duan, Associate Chief Physician, PhD, Department of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1519 Dongyue Avenue, Nanchang 330000, Jiangxi Province, China. duanjy2022@outlook.com
Key Words	Bariatric surgery; Mid to distal bowel resection; Gut microbiota; Bile acids; Gluconeogenesis
Core Tip	Distal small bowel resection with preservation of the terminal ileum (DBRPI) improves glucose tolerance and reduces weight in high-fat diet-fed rats. This effect is linked to altered gut microbiota and bile acids: Increased Prevotellaceae_NK3B31_group and 7-ketolithocholic acid (7-KLCA), alongside decreased Desulfovibrio fairfieldensis and α-muricholic acid. DBRPI upregulates ileal farnesoid X receptor (FXR) and glucagon-like peptide-1 (GLP-1) expression, and downregulates hepatic gluconeogenic genes. Critically, Prevotellaceae_NK3B31_group correlates positively with 7-KLCA and FXR, and negatively with glucose intolerance and gluconeogenesis. Thus, DBRPI likely improves glucose metabolism by activating the Prevotellaceae-mediated 7-KLCA-FXR pathway, enhancing GLP-1, and suppressing hepatic glucose production.
Publish Date	2025-11-20 07:56
Citation	<p>Xu CY, Zheng ZH, Yang K, Wu RR, Cao JQ, Duan JY. Distal small bowel resection with preservation of the terminal ileum suppresses hepatic gluconeogenesis via the Prevotellaceae_NK3B31_group-mediated 7-KLCA-FXR axis. <i>World J Gastroenterol</i> 2025; 31(43): 112483</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i43/112483.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i43.112483

Full Article (PDF)	WJG-31-112483-with-cover.pdf
The ARRIVE Guidelines	112483-The-ARRIVE-Guidelines.pdf
Manuscript File	112483_Auto_Edited_075618.docx
Answering Reviewers	112483-answering-reviewers.pdf
Audio Core Tip	112483-audio.mp3
Biostatistics Review Certificate	112483-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	112483-conflict-of-interest-statement.pdf
Copyright License Agreement	112483-copyright-assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	112483-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	112483-non-native-speakers.pdf
Peer-review Report	112483-peer-reviews.pdf
Scientific Misconduct Check	112483-scientific-misconduct-check.png
Scientific Editor Work List	112483-scientific-editor-work-list.pdf
CrossCheck Report	112483-crosscheck-report.pdf