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Articles Published Processes
11/20/2025 7:56:47 AM | Browse: 86 | Download: 346
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Received |
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2025-07-29 05:04 |
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Peer-Review Started |
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2025-07-29 05:05 |
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First Decision by Editorial Office Director |
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2025-08-19 10:13 |
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Return for Revision |
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2025-08-19 10:13 |
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Revised |
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2025-09-02 03:07 |
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Publication Fee Transferred |
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2025-09-08 15:24 |
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Second Decision by Editor |
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2025-10-13 02:50 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-13 06:16 |
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Articles in Press |
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2025-10-13 06:16 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-07 08:35 |
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Publish the Manuscript Online |
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2025-11-20 07:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Distal small bowel resection with preservation of the terminal ileum suppresses hepatic gluconeogenesis via the Prevotellaceae_NK3B31_group-mediated 7-KLCA-FXR axis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chi-Ying Xu, Zhi-Hua Zheng, Kun Yang, Ren-Ran Wu, Jia-Qing Cao and Jin-Yuan Duan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82360168 and 81960154 |
| Natural Science Foundation of Jiangxi Province |
20212BAB206020 |
| Foundation of Health Commission of Jiangxi Province |
202310024 |
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| Corresponding Author |
Jin-Yuan Duan, Associate Chief Physician, PhD, Department of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1519 Dongyue Avenue, Nanchang 330000, Jiangxi Province, China. duanjy2022@outlook.com |
| Key Words |
Bariatric surgery; Mid to distal bowel resection; Gut microbiota; Bile acids; Gluconeogenesis |
| Core Tip |
Distal small bowel resection with preservation of the terminal ileum (DBRPI) improves glucose tolerance and reduces weight in high-fat diet-fed rats. This effect is linked to altered gut microbiota and bile acids: Increased Prevotellaceae_NK3B31_group and 7-ketolithocholic acid (7-KLCA), alongside decreased Desulfovibrio fairfieldensis and α-muricholic acid. DBRPI upregulates ileal farnesoid X receptor (FXR) and glucagon-like peptide-1 (GLP-1) expression, and downregulates hepatic gluconeogenic genes. Critically, Prevotellaceae_NK3B31_group correlates positively with 7-KLCA and FXR, and negatively with glucose intolerance and gluconeogenesis. Thus, DBRPI likely improves glucose metabolism by activating the Prevotellaceae-mediated 7-KLCA-FXR pathway, enhancing GLP-1, and suppressing hepatic glucose production. |
| Publish Date |
2025-11-20 07:56 |
| Citation |
Xu CY, Zheng ZH, Yang K, Wu RR, Cao JQ, Duan JY. Distal small bowel resection with preservation of the terminal ileum suppresses hepatic gluconeogenesis via the Prevotellaceae_NK3B31_group-mediated 7-KLCA-FXR axis. World J Gastroenterol 2025; 31(43): 112483 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i43/112483.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i43.112483 |
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