BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
11/26/2025 3:57:03 AM | Browse: 82 | Download: 286
 |
Received |
|
2025-07-28 14:42 |
|
Peer-Review Started |
|
2025-07-28 14:42 |
|
First Decision by Editorial Office Director |
|
2025-08-19 09:26 |
|
Return for Revision |
|
2025-08-19 09:26 |
|
Revised |
|
2025-09-02 11:05 |
|
Publication Fee Transferred |
|
2025-09-03 06:29 |
|
Second Decision by Editor |
|
2025-09-29 00:37 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2025-10-09 08:11 |
|
Articles in Press |
|
2025-10-09 08:11 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2025-11-20 02:13 |
|
Publish the Manuscript Online |
|
2025-11-26 03:57 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
HIF-1α modulates β-catenin pathway to enhance the survival and angiogenesis of PBMSCs under hypoxia environment
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Peng-Zhen Wang, Ai-Qun Wang, Ping-Ge Tian, Ping-Ping Zhu, Wei Yuan, Jian Wu and Rui Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangdong Provincial Natural Science Foundation General Program |
2025A1515012455 |
| Guangzhou Municipal Science and Technology Project |
2024A03J0653, 2023A03J0595 |
| Guangzhou Municipal Science and Technology Project |
2023A03J0510, 2023A03J0528 |
|
| Corresponding Author |
Rui Zhang, Chief Physician, MD, Department of Emergency, Guangzhou Red Cross Hospital of Jinan University, No. 396 Tongfu Middle Road, Guangzhou 510220, Guangdong Province, China. 63281796@qq.com |
| Key Words |
Angiogenesis; Hypoxia-inducible factor-1α; Myocardial infarction; Peripheral blood mesenchymal stem cells; β-catenin |
| Core Tip |
The finding of this study indicates that hypoxia-inducible factor-1α (HIF-1α) and β-catenin facilitate peripheral blood mesenchymal stem cells (PBMSCs) self-renewal and inhibit PBMSCs apoptosis. In vivo, PBMSCs with upregulated HIF-1α achieved enhanced retention within infarcted myocardial and contributed markedly to myocardial regeneration. These observations highlight the modulatory role of HIF-1α in modulating PBMSCs function via β-catenin-dependent anti-apoptotic and pro-angiogenic pathway, thereby offering a potential strategy to improve the longevity and therapeutic efficacy of PBMSCs. |
| Publish Date |
2025-11-26 03:57 |
| Citation |
Wang PZ, Wang AQ, Tian PG, Zhu PP, Yuan W, Wu J, Zhang R. HIF-1α modulates β-catenin pathway to enhance the survival and angiogenesis of PBMSCs under hypoxia environment. World J Stem Cells 2025; 17(11): 112484 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i11/112484.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i11.112484 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
