| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Formononetin inhibits p53 signaling pathway activation to delay cellular senescence and ameliorates diabetic kidney disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yue Ji, Rui-Xin Liu, Pei-Yue He, Yi-Min Zhou, Ya-Chun Li, Jing Guo, Bo Nie, Yu-Ning Liu and Wei-Jing Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China Youth Program |
82405313 |
| National Natural Science Foundation of China Youth Program |
82204821 |
| National Natural Science Foundation of China Youth Program |
82205037 |
| National Natural Science Foundation of China |
82274293 |
| Dongzhimen Hospital Grant |
DZMG-XZYY-23002 |
| Dongzhimen Hospital Grant |
DZMG-ZJXY-23004 |
| Dongzhimen Hospital Grant |
DZMG-QNZX-24005 |
| the China Postdoctoral Science Foundation |
2024M760287 |
| National Major Science and Technology Project |
2025ZD0549600 |
|
| Corresponding Author |
Wei-Jing Liu, Academic Fellow, Professor, Institute of Nephrology & Beijing Key Laboratory, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, No. 5, Haiyuncang, Dongcheng District, Beijing, Beijing 100010, China. liuweijing-1977@hotmail.com |
| Key Words |
Formononetin; Diabetic kidney disease; p53 signaling pathway; Cellular senescence; Transcriptomics |
| Core Tip |
Transcriptomic profiling identified the p53 signaling pathway as the key mechanism through which formononetin (FN) alleviates diabetic kidney disease (DKD). FN upregulates MDM2 expression, thereby inhibiting p53 transcriptional activity—as confirmed by dual-luciferase reporter assay—and downregulating p21, leading to reduced senescence markers (β-galactosidase and senescence-associated secretory phenotype factors) in both podocytes and DKD mice. Notably, MDM2 gene silencing abrogates the anti-senescent effects of FN, establishing MDM2 as essential to its action. Overall, FN improves renal function and pathology by targeting the p53/MDM2/p21 axis to attenuate cellular senescence. |
| Publish Date |
2026-02-06 08:43 |
| Citation |
Ji Y, Liu RX, He PY, Zhou YM, Li YC, Guo J, Nie B, Liu YN, Liu WJ. Formononetin inhibits p53 signaling pathway activation to delay cellular senescence and ameliorates diabetic kidney disease. World J Diabetes 2026; 17(2): 112500 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i2/112500.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i2.112500 |
