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Articles Published Processes
11/13/2025 6:51:10 AM | Browse: 16 | Download: 51
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Received |
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2025-07-31 02:26 |
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Peer-Review Started |
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2025-07-31 02:26 |
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To Make the First Decision |
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Return for Revision |
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2025-09-09 10:12 |
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Revised |
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2025-09-23 03:58 |
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Second Decision |
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2025-10-20 02:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-10-20 06:14 |
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Articles in Press |
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2025-10-20 06:14 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2025-10-27 08:49 |
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Typeset the Manuscript |
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2025-11-05 09:13 |
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Publish the Manuscript Online |
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2025-11-13 06:51 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Hydrogen peroxide pathway in ulcerative colitis: Promises and challenges in translating novel pathogenesis to clinical practice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Yu Wang, Fan An, Ben-Jun Wang and Wei-Wei Han |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wei-Wei Han, Associate Professor, PhD, Anorectal Research, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No. 16369 Jingshi Road, Lixia District, Jinan, Shandong, China, jinan 250014, Shandong Province, China. hanweiwei0557@163.com |
| Key Words |
Ulcerative colitis; Hydrogen peroxide; Pathogenesis; Reducing agents; Therapeutic targets |
| Core Tip |
Pravda's hydrogen peroxide (H2O2) hypothesis provides mechanistic insights for ulcerative colitis but faces several clinical translation challenges. These include difficulties in H2O2 measurement, limited safety data for reducing agents, and the risk of patients abandoning proven therapies. We recommend conducting phase II trials, comprehensive safety assessments, and research approaches that integrate redox mechanisms with established frameworks. Collaborative strategies that balance scientific exploration with patient safety may ensure appropriate validation before clinical adoption. |
| Publish Date |
2025-11-13 06:51 |
| Citation |
<p>Wang XY, An F, Wang BJ, Han WW. Hydrogen peroxide pathway in ulcerative colitis: Promises and challenges in translating novel pathogenesis to clinical practice. <i>World J Gastroenterol</i> 2025; 31(42): 112566</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i42/112566.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i42.112566 |
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