| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Phenotypic and functional characteristics of pituitary adenoma stem cells
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Edoardo Agosti, Lorenzo Gelmini, Pier Paolo Panciani, Alessandro Fiorindi, Marco Maria Fontanella, Francesco Tengattini, Luca Denaro, Caterina Gagliano, Daniele Tognetto and Marco Zeppieri |
| ORCID |
|
| Funding Agency and Grant Number |
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| Corresponding Author |
Marco Zeppieri, MD, PhD, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it |
| Key Words |
Pituitary neuroendocrine tumors; Stem cells; Tumorigenesis; Therapy resistance; Pituitary adenoma stem cells; Pathway |
| Core Tip |
Pituitary adenoma stem cells are a functionally distinct subpopulation within pituitary neuroendocrine tumors, exhibiting stem-like traits such as self-renewal, multipotency, and resistance to dopamine agonists and somatostatin analogs. This systematic review consolidates evidence from 34 studies, highlighting the expression of key markers like SRY-related HMG-box transcription factor 2, CD133, and Nestin, and the involvement of dysregulated pathways including Wnt/beta-catenin, Notch, Sonic hedgehog. Pituitary adenoma stem cells are implicated in tumorigenesis, invasion, and recurrence, making them compelling targets for future therapies aimed at overcoming resistance and preventing relapse in pituitary neuroendocrine tumors. |
| Publish Date |
2025-12-16 06:42 |
| Citation |
Agosti E, Gelmini L, Panciani PP, Fiorindi A, Fontanella MM, Tengattini F, Denaro L, Gagliano C, Tognetto D, Zeppieri M. Phenotypic and functional characteristics of pituitary adenoma stem cells. World J Clin Cases 2025; 13(35): 112585 |
| URL |
https://www.wjgnet.com/2307-8960/full/v13/i35/112585.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v13.i35.112585 |
