| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Basic Study |
| Article Title |
Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn’s disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Albert Boronat-Toscano, Maria Isabel Queipo-Ortuño, Diandra Monfort-Ferré, Roger Suau, Irene Vañó-Segarra, Gemma Valldosera, Claudia Cepero, Brenno Astiarraga, Laura Clua-Ferré, Isaac Plaza-Andrade, Lucía Aranega-Martín, Lidia Cabrinety, Carme Abadia de Barbarà, Daniel Castellano-Castillo, Alicia Moliné, Aleidis Caro, Eugeni Domènech, Jose Francisco Sánchez-Herrero, Robert Benaiges-Fernandez, Sonia Fernández-Veledo, Joan Vendrell, Iris Ginés, Lauro Sumoy, Josep Manyé, Margarita Menacho and Carolina Serena |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the grant from I Clinical GETECCU_Galapagos |
|
| the grant from the Ministerio de Ciencia, Innovación y Universidades |
PID2023-146315OB-I00 |
| the grant by the Instituto Salud Carlos III |
PI20/00420, PI22/01498 |
| the grant |
PI-AGAUR 2022-B00577 |
|
| Corresponding Author |
Carolina Serena, Head, Principal Investigator, Hospital Universitari Joan XXIII, Institut d’Investigació Sanitària Pere Virgili, C/Escorxador s/n, Tarragona 43007, Catalonia, Spain. carolina.serena@iispv.cat |
| Key Words |
Succinate; Dialister; Biomarker; Postoperative recurrence; Inflammatory bowel diseases; Succinic acid; Gut microbiota; Prevotella; Escherichia coli |
| Core Tip |
The study reported that circulating succinate, a microbial and host metabolite, are markedly elevated in patients with Crohn’s disease. Interestingly, we found that succinate strongly correlates with inflammatory activity and is linked to changes in the gut microbiota, including an increased abundance of the slow succinate consumer genera Dialister. Importantly, the presence of the Dialister in intestinal tissue was also associated with post-operative recurrence in these patients. These findings highlight succinate as a promising biomarker for disease activity and progression in Crohn’s disease and suggest that targeting succinate metabolism or modulating specific microbial taxa could open new therapeutic opportunities. |
| Publish Date |
2025-12-03 09:10 |
| Citation |
Boronat-Toscano A, Queipo-Ortuño MI, Monfort-Ferré D, Suau R, Vañó-Segarra I, Valldosera G, Cepero C, Astiarraga B, Clua-Ferré L, Plaza-Andrade I, Aranega-Martín L, Cabrinety L, Abadia de Barbarà C, Castellano-Castillo D, Moliné A, Caro A, Domènech E, Sánchez-Herrero JF, Benaiges-Fernandez R, Fernández-Veledo S, Vendrell J, Ginés I, Sumoy L, Manyé J, Menacho M, Serena C. Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn’s disease. World J Gastroenterol 2025; 31(45): 112618 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i45/112618.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i45.112618 |
