| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Yin Yang 1 activates JAK-STAT3-mediated epithelial-mesenchymal transition in Helicobacter pylori-induced gastric cancer progression
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing-Wan Chen, Jie-Ji Ouyang, Zhen-Hui Wang, Di-Meng Ma, Zhi Zhang, Qiong Teng, Gang Yu and Xiang-Yong Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82372646 |
| Research Fund of Anhui Institute of Translational Medicine |
No. 2023zhyx-C70 and No. 2023zhyx-C80 |
|
| Corresponding Author |
Xiang-Yong Li, Chief Physician, PhD, Professor, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Shushan District, Hefei 230022, Anhui Province, China. liyongxiang@ahmu.edu.cn |
| Key Words |
Helicobacter pylori; Gastric cancer; Yin Yang 1; Janus kinase 2/signal transducer and activator of transcription 3; Epithelial-mesenchymal transition |
| Core Tip |
This study revealed that Yin Yang 1 (YY1) was upregulated in Helicobacter pylori-induced gastritis and gastric cancer, where it promoted tumor proliferation, invasion, epithelial-mesenchymal transition, and growth by directly activating Janus kinase 2 transcription and enhancing Janus kinase 2/signal transducer and activator of transcription 3 phosphorylation. YY1 knockdown or pharmacological inhibition reversed these malignant phenotypes. These findings elucidate a key mechanistic pathway in gastric carcinogenesis and identify YY1 as a potential therapeutic target for Helicobacter pylori-associated malignancy. |
| Publish Date |
2025-12-23 06:25 |
| Citation |
Chen JW, Ouyang JJ, Wang ZH, Ma DM, Zhang Z, Teng Q, Yu G, Li XY. Yin Yang 1 activates JAK-STAT3-mediated epithelial-mesenchymal transition in Helicobacter pylori-induced gastric cancer progression. World J Clin Oncol 2025; 16(12): 112626 |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i12/112626.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i12.112626 |
