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Articles Published Processes
10/27/2025 8:08:13 AM | Browse: 176 | Download: 447
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Received |
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2025-08-04 12:15 |
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Peer-Review Started |
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2025-08-04 12:15 |
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First Decision by Editorial Office Director |
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2025-08-14 11:23 |
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Return for Revision |
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2025-08-14 11:23 |
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Revised |
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2025-08-26 12:38 |
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Publication Fee Transferred |
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2025-08-30 10:08 |
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Second Decision by Editor |
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2025-09-23 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-23 06:30 |
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Articles in Press |
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2025-09-23 06:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-21 02:24 |
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Publish the Manuscript Online |
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2025-10-27 08:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Comprehensive microbial and clinical profiling of functional constipation: A stratified comparative study of age and constipation subtype
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui-Ting Zhu, Hui-Fen Wang, Qin Zhang, Ju-Fang Bai, Miao Wang, Shi-Yu Du and Yan-Li Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| China Medical and Health Development Foundation |
No. 2022-HX-76 |
| China-Japan Friendship Hospital High-level Hospital Clinical Business Expenses Special Project |
No. 2023-NHLHCRF-YYPPLC-ZR-19 |
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| Corresponding Author |
Yan-Li Zhang, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 East Yinghua Street, Chaoyang District, Beijing 100029, China. 13521234067@163.com |
| Key Words |
Gut microbiota; Functional constipation; Gastrointestinal disorder; Microbial diversity; Age-related differences |
| Core Tip |
This study highlights the distinct gut microbiota profiles associated with age and constipation subtypes in patients with functional constipation (FC). Using 16S rRNA sequencing, we found significant age-related differences in microbial diversity and composition, with older adults exhibiting reduced richness and beneficial taxa. Constipation subtypes also showed distinct microbial patterns, with slow-transit constipation enriched in taxa linked to reduced motility and defecatory disorder characterized by motility-promoting microbes. These findings underscore the pathophysiological heterogeneity of FC and support the development of age- and subtype-specific microbiota-targeted therapies for precision diagnosis and treatment. |
| Publish Date |
2025-10-27 08:08 |
| Citation |
Zhu HT, Wang HF, Zhang Q, Bai JF, Wang M, Du SY, Zhang YL. Comprehensive microbial and clinical profiling of functional constipation: A stratified comparative study of age and constipation subtype. World J Gastroenterol 2025; 31(40): 112637 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i40/112637.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i40.112637 |
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