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Articles Published Processes
11/6/2025 8:56:34 AM | Browse: 3 | Download: 0
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Received |
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2025-08-07 01:50 |
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Peer-Review Started |
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2025-08-07 01:50 |
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To Make the First Decision |
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Return for Revision |
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2025-08-25 07:59 |
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Revised |
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2025-09-10 14:19 |
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Second Decision |
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2025-09-28 02:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-28 08:23 |
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Articles in Press |
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2025-09-28 08:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-28 06:36 |
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Publish the Manuscript Online |
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2025-11-06 08:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
RGS4 in gastric cancer: A multifaceted regulator of focal-adhesion-kinase -phosphatidyl-inositol-3-kinase - protein-kinase-B signaling and epithelial-mesenchymal transition beyond tumor progression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yun Yang and Wen-Ming Chen |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wen-Ming Chen, Associate Chief Physician, MD, Department of Oncology, Jining No. 1 People’s Hospital, No. 6 Jiankang Road, Jining 272011, Shandong Province, China. yusuker9950529@163.com |
| Key Words |
RGS4; Focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B; Epithelial-mesenchymal transition; Gastric cancer; Biomarker; Preclinical model |
| Core Tip |
Chen et al provided compelling multilevel evidence that regulator of G-protein signaling 4 drives gastric cancer progression through focal adhesion kinase/phosphoinositide 3-kinase/protein kinase B activation and epithelial-mesenchymal transition, combining clinical correlation with functional validation. Although further mechanistic studies and expanded clinical cohorts would strengthen the findings, this work establishes G-protein signaling 4 as a promising therapeutic target worthy of deeper investigation. |
| Publish Date |
2025-11-06 08:56 |
| Citation |
<p>Yang Y, Chen WM. RGS4 in gastric cancer: A multifaceted regulator of focal-adhesion-kinase -phosphatidyl-inositol-3-kinase - protein-kinase-B signaling and epithelial-mesenchymal transition beyond tumor progression. <i>World J Gastroenterol</i> 2025; 31(41): 112642</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i41/112642.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i41.112642 |
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