| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Combined metabolomic and metagenomic analysis reveals inflammatory bowel disease diversity in pediatric and adult patients
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Natalya B Zakharzhevskaya, Svetlana I Erdes, Elena A Belousova, Ivan S Samolygo, Marina A Manina, Polina V Kondrashova, Ekaterina Y Lomakina, Dmitry A Kardonsky, Elizaveta A Vorobyeva, Olga Y Shagaleeva, Artemiy A Silantyev, Victoriia D Kazakova, Daria A Kashatnikova, Tatiana N Kalachnuk, Irina V Kolesnikova, Andrey V Chaplin, Maria I Markelova, Tatiana V Grigoryeva, Evgenii I Olekhnovich, Vladimir A Veselovsky, Maxim D Morozov, Polina Y Zoruk, Daria I Boldyreva, Anna A Vanyushkina and Boris A Efimov |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| IBD-ONCO 25-27 project |
No. R&D 125030703327-1 |
|
| Corresponding Author |
Natalya B Zakharzhevskaya, PhD, Postdoc, Professor, Department of Postgenomics, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Malaya Pirogovskaya, 1A, Moscow 119435, Russia. natazaha@gmail.com |
| Key Words |
Headspace-gas chromatography-mass spectrometry; Inflammatory bowel disease; Crohn’s disease; Ulcerative colitis; Metagenomics; Pediatric and adult patients |
| Core Tip |
Functional metabolomics combines the ability to simultaneously assess the diversity of the microbiome and evaluate its secretory activity in the development of pathologies. In this study, a diagnostic rule was developed for children with inflammatory bowel disease that enables calculation of the risk of disease development. This rule, based on a set of metabolic and metagenomic markers, also helps clarify the specific type of pathology. The combined use of metabolomic and metagenomic analysis will facilitate prompt assessment of the potential risks for developing inflammatory bowel disease in the future and support timely initiation of appropriate therapy. |
| Publish Date |
2025-12-27 02:50 |
| Citation |
Zakharzhevskaya NB, Erdes SI, Belousova EA, Samolygo IS, Manina MA, Kondrashova PV, Lomakina EY, Kardonsky DA, Vorobyeva EA, Shagaleeva OY, Silantyev AA, Kazakova VD, Kashatnikova DA, Kalachnuk TN, Kolesnikova IV, Chaplin AV, Markelova MI, Grigoryeva TV, Olekhnovich EI, Veselovsky VA, Morozov MD, Zoruk PY, Boldyreva DI, Vanyushkina AA, Efimov BA. Combined metabolomic and metagenomic analysis reveals inflammatory bowel disease diversity in pediatric and adult patients. World J Gastroenterol 2025; 31(48): 112653 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i48/112653.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i48.112653 |
