12/10/2025 7:48:09 AM | Browse: 3 | Download: 15
| Publication Name | World Journal of Gastroenterology |
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| Manuscript ID | 112664 |
| Country | China |
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| ISSN | 1007-9327 (print) and 2219-2840 (online) |
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| Open Access | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright | © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Gastroenterology & Hepatology | ||||||||||||||||||||||||||||||||
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| Manuscript Type | Basic Study | ||||||||||||||||||||||||||||||||
| Article Title | Ethnic genomic differences in esophageal squamous cell carcinoma: Whole-exome sequencing of Han and Kazakh populations in China | ||||||||||||||||||||||||||||||||
| Manuscript Source | Unsolicited Manuscript | ||||||||||||||||||||||||||||||||
| All Author List | Meng-Xia Wei, Ling-Ling Lei, Rui-Hua Xu, Yong-Xuan Liu, Ran Wang, Wen-Li Han, Zong-Min Fan, Fan-Kai Xiao, Ilyar Sheyhidin, Lei Ma, Jian-Wei Ku, Ming-Zhu Yin, Ai-Fang Ji, Qi-De Bao, She-Gan Gao, Xue-Na Han, Xin-Min Li, Pei-Nan Chen, Xue-Ke Zhao, Xin Song and Li-Dong Wang | ||||||||||||||||||||||||||||||||
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| Corresponding Author | Li-Dong Wang, MD, PhD, Professor, Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolic Dysregulation and Esophageal Cancer Prevention and Treatment, The First Affiliated Hospital of Zhengzhou University, No. 40 Daxue Road, Zhengzhou 450052, Henan Province, China. ldwang2007@126.com | ||||||||||||||||||||||||||||||||
| Key Words | Esophageal squamous cell carcinoma; Han; Kazakh; Ethnic difference; Whole-exome sequencing; Diet; Apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide; Single base substitutions 6 | ||||||||||||||||||||||||||||||||
| Core Tip | This study aimed to explore if ethnic differences (Han vs Kazakh) cause molecular variations in Chinese esophageal squamous cell carcinoma (ESCC) patients, affecting treatment response. It sequenced 299 ESCC samples, found ethnic differences in difference genes (e.g., GIGYF1), tumor mutation burden, mutational signatures (apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide/single base substitutions 6), linked to environment/diet. Results may guide ethnic-specific ESCC treatment. | ||||||||||||||||||||||||||||||||
| Publish Date | 2025-12-10 07:48 | ||||||||||||||||||||||||||||||||
| Citation | Wei MX, Lei LL, Xu RH, Liu YX, Wang R, Han WL, Fan ZM, Xiao FK, Sheyhidin I, Ma L, Ku JW, Yin MZ, Ji AF, Bao QD, Gao SG, Han XN, Li XM, Chen PN, Zhao XK, Song X, Wang LD. Ethnic genomic differences in esophageal squamous cell carcinoma: Whole-exome sequencing of Han and Kazakh populations in China. World J Gastroenterol 2025; 31(46): 112664 |
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| URL | https://www.wjgnet.com/1007-9327/full/v31/i46/112664.htm | ||||||||||||||||||||||||||||||||
| DOI | https://dx.doi.org/10.3748/wjg.v31.i46.112664 |
| Full Article (PDF) | WJG-31-112664-with-cover.pdf |
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| Manuscript File | 112664_Auto_Edited_020639.docx |
| Answering Reviewers | 112664-answering-reviewers.pdf |
| Audio Core Tip | 112664-audio.mp3 |
| Biostatistics Review Certificate | 112664-biostatistics-statement.pdf |
| Conflict-of-Interest Disclosure Form | 112664-conflict-of-interest-statement.pdf |
| Copyright License Agreement | 112664-copyright-assignment.pdf |
| Institutional Review Board Approval Form or Document | 112664-institutional-review-board-statement.pdf |
| Non-Native Speakers of English Editing Certificate | 112664-non-native-speakers.pdf |
| Supplementary Material | 112664-supplementary-material.pdf |
| Peer-review Report | 112664-peer-reviews.pdf |
| Scientific Misconduct Check | 112664-scientific-misconduct-check.png |
| Scientific Editor Work List | 112664-scientific-editor-work-list.pdf |
| CrossCheck Report | 112664-crosscheck-report.pdf |