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11/27/2025 7:53:53 AM | Browse: 10 | Download: 44
Publication Name World Journal of Hepatology
Manuscript ID 112679
Country Egypt
Received
2025-08-04 09:19
Peer-Review Started
2025-08-04 09:19
First Decision by Editorial Office Director
2025-08-15 09:05
Return for Revision
2025-08-15 09:05
Revised
2025-08-18 14:21
Publication Fee Transferred
Second Decision by Editor
2025-09-28 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-09-28 06:55
Articles in Press
2025-09-28 06:55
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-10-31 13:06
Publish the Manuscript Online
2025-11-27 07:53
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Letter to the Editor
Article Title Tumor necrosis factor alpha-induced protein 3: Biomarker discovery and therapeutic advancement in primary biliary cholangitis
Manuscript Source Unsolicited Manuscript
All Author List Khaled Mohamed Mohamed Koriem
ORCID
Author(s) ORCID Number
Khaled Mohamed Mohamed Koriem http://orcid.org/0000-0002-1323-1700
Funding Agency and Grant Number
Corresponding Author Khaled Mohamed Mohamed Koriem, Professor, Department of Medical Physiology, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Buhouth Street, Dokki, P.O. Box, Giza 12622, Egypt. kkoriem@yahoo.com
Key Words Tumor necrosis factor alpha-induced protein 3; Ursodeoxycholic acid; Fatigue; Biomarkers prediction; Primary biliary cholangitis treatment
Core Tip The novel work by Zang et al examined tumor necrosis factor alpha-induced protein 3 (TNFAIP3), a new biomarker, to predict ursodeoxycholic acid (UDCA) efficiency in primary biliary cholangitis (PBC). PBC patients' TNFAIP3 expression was significantly higher than that in healthy controls. The response to UDCA in PBC was substantially impacted by both TNFAIP3 and fatigue. TNFAIP3 may be a suitable biomarker or therapeutic target for PBC because its expression was also connected with splenomegaly, alkaline phosphatase, albumin, total bilirubin, and age.
Publish Date 2025-11-27 07:53
Citation

Koriem KMM. Tumor necrosis factor alpha-induced protein 3: Biomarker discovery and therapeutic advancement in primary biliary cholangitis. World J Hepatol 2025; 17(11): 112679

URL https://www.wjgnet.com/1948-5182/full/v17/i11/112679.htm
DOI https://dx.doi.org/10.4254/wjh.v17.i11.112679
Full Article (PDF) WJH-17-112679-with-cover.pdf
Manuscript File 112679_Auto_Edited_022041.docx
Answering Reviewers 112679-answering-reviewers.pdf
Audio Core Tip 112679-audio.mp3
Conflict-of-Interest Disclosure Form 112679-conflict-of-interest-statement.pdf
Copyright License Agreement 112679-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 112679-non-native-speakers.pdf
Peer-review Report 112679-peer-reviews.pdf
Scientific Misconduct Check 112679-scientific-misconduct-check.png
Scientific Editor Work List 112679-scientific-editor-work-list.pdf
CrossCheck Report 112679-crosscheck-report.pdf