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Articles Published Processes
11/26/2025 3:57:04 AM | Browse: 13 | Download: 95
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Received |
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2025-08-04 06:37 |
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Peer-Review Started |
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2025-08-04 06:37 |
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First Decision by Editorial Office Director |
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2025-09-08 09:52 |
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Return for Revision |
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2025-09-08 09:52 |
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Revised |
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2025-09-16 13:07 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-05 02:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-06 09:56 |
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Articles in Press |
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2025-11-06 09:56 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-18 07:29 |
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Publish the Manuscript Online |
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2025-11-26 03:57 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Dentistry, Oral Surgery & Medicine |
| Manuscript Type |
Review |
| Article Title |
Post-translational modifications in the oral microenvironment: Stem cell regulation from periodontal regeneration to oral cancer therapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Wei Liu, Yuan-Yuan Yang and Zhuo-Jin Shi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zhuo-Jin Shi, DDS, School/Hospital of Stomatology, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou 310053, Zhejiang Province, China. shizhuojin@yeah.net |
| Key Words |
Dental-derived mesenchymal stem cells; Post-translational modifications; Periodontal regeneration; Oral squamous cell carcinoma; Cancer stem-cell plasticity |
| Core Tip |
Post-translational modifications act as dynamic molecular codes that steer dental-derived mesenchymal stem cells through a continuum from periodontal regeneration to oral squamous cell carcinoma stem-cell plasticity. This review integrates single-cell and spatial multi-omics evidence to map a sequential cascade - acetylation, crotonylation, phosphorylation, trimethylation, ubiquitination and N6-methyladenosine RNA methylation - that reprograms lineage commitment, immune evasion and therapy resistance. Identifying tractable post-translational modification enzymes (e.g., general control non-depressible 5, enhancer of zeste homolog 2, methyltransferase-like 3) clarifies actionable levers for regeneration and oncology. |
| Publish Date |
2025-11-26 03:57 |
| Citation |
Liu W, Yang YY, Shi ZJ. Post-translational modifications in the oral microenvironment: Stem cell regulation from periodontal regeneration to oral cancer therapy. World J Stem Cells 2025; 17(11): 112702 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i11/112702.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i11.112702 |
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