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Articles Published Processes
1/12/2026 10:07:42 AM | Browse: 1 | Download: 15
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Received |
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2025-08-15 08:20 |
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Peer-Review Started |
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2025-08-15 08:20 |
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First Decision by Editorial Office Director |
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2025-09-09 09:26 |
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Return for Revision |
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2025-09-09 09:26 |
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Revised |
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2025-09-22 13:59 |
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Publication Fee Transferred |
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2025-09-24 02:11 |
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Second Decision by Editor |
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2025-12-02 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-02 10:15 |
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Articles in Press |
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2025-12-02 10:15 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-04 02:08 |
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Publish the Manuscript Online |
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2026-01-12 10:07 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Muscle mass correlates with rocuronium distribution volume and guides dose optimization in obese colorectal cancer patients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhan-Wen Li, Zhe Liu and Sheng-Qun Liu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Sheng-Qun Liu, Chief Physician, Department of Anesthesia and Perioperative Medicine, Henan Provincial People’s Hospital (Zhengzhou University People’s Hospital), No. 7 Weiwu Road, Zhengzhou 450003, Henan Province, China. liushengqunhx@163.com |
| Key Words |
Obesity; Rocuronium; Skeletal muscle index; Population pharmacokinetics; Individualized dosing; Colorectal cancer; Sarcopenia |
| Core Tip |
This study established a population pharmacokinetic model of rocuronium in obese patients with colorectal cancer, incorporating skeletal muscle index to explore its effect on drug distribution volume. Using nonlinear mixed-effects modeling and Monte Carlo simulation, we developed an individualized dosing strategy based on muscle mass. The findings reveal that skeletal muscle index is a significant covariate influencing rocuronium pharmacokinetic, providing a scientific basis for optimizing anesthetic dosing in obese surgical patients and enhancing patient safety during colorectal cancer surgery. |
| Publish Date |
2026-01-12 10:07 |
| Citation |
Li ZW, Liu Z, Liu SQ. Muscle mass correlates with rocuronium distribution volume and guides dose optimization in obese colorectal cancer patients. World J Gastrointest Oncol 2026; 18(1): 112742 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i1/112742.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i1.112742 |
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