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Articles Published Processes
12/25/2025 3:52:07 AM | Browse: 4 | Download: 27
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Received |
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2025-08-06 14:46 |
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Peer-Review Started |
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2025-08-06 14:47 |
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First Decision by Editorial Office Director |
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2025-09-12 06:56 |
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Return for Revision |
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2025-09-12 06:56 |
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Revised |
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2025-09-16 11:58 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-10 02:48 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-12 05:31 |
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Articles in Press |
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2025-11-12 05:31 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-18 03:08 |
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Publish the Manuscript Online |
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2025-12-25 03:52 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Does standalone/combined subchondral bone marrow-derived mesenchymal stem/stromal cell injection offer significantly better clinical benefit to intraarticular injection in knee osteoarthritis?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Arulkumar Nallakumarasamy, Sandeep Shrivastava, Ravi Velamoor Rangarajan, Naveen Jeyaraman, Avinash Gandi Devadas, Swaminathan Ramasubramanian, Sathish Muthu, Asawari Bapat and Madhan Jeyaraman |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Madhan Jeyaraman, MD, PhD, Department of Orthopaedics, ACS Medical College and Hospital, Dr. MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com |
| Key Words |
Orthobiologics; Regenerative medicine; Bone marrow lesions; Mesenchymal stem cells; Intra-articular injection; Subchondral injection; Bone marrow aspirate concentrate; Knee osteoarthritis |
| Core Tip |
Subchondral bone-targeted bone marrow aspirate concentrate therapy offers a promising biologic approach for knee osteoarthritis, outperforming intra-articular delivery in symptom relief and structural preservation. Addressing bone marrow lesions and mesenchymal stem cell depletion within the subchondral zone enhances pain scores, functional outcomes, and cartilage integrity while delaying total knee arthroplasty. These findings support a paradigm shift toward whole-joint biologic interventions that modify disease progression rather than merely alleviating symptoms. |
| Publish Date |
2025-12-25 03:52 |
| Citation |
Nallakumarasamy A, Shrivastava S, Rangarajan RV, Jeyaraman N, Devadas AG, Ramasubramanian S, Muthu S, Bapat A, Jeyaraman M. Does standalone/combined subchondral bone marrow-derived mesenchymal stem/stromal cell injection offer significantly better clinical benefit to intraarticular injection in knee osteoarthritis? World J Stem Cells 2025; 17(12): 112778 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i12/112778.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i12.112778 |
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