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12/15/2025 9:46:06 AM | Browse: 8 | Download: 49
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Received |
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2025-08-06 15:20 |
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Peer-Review Started |
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2025-08-07 00:30 |
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First Decision by Editorial Office Director |
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2025-09-22 09:12 |
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Return for Revision |
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2025-09-22 09:12 |
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Revised |
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2025-09-29 14:46 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-22 02:12 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-29 09:47 |
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Articles in Press |
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2025-10-29 09:47 |
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Edit the Manuscript by Language Editor |
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2025-11-03 07:48 |
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Typeset the Manuscript |
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2025-11-21 08:54 |
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Publish the Manuscript Online |
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2025-12-15 09:46 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Methylation status of leptin gene promoter in relatively lean Chinese adults with prediabetes and type 2 diabetes mellitus
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Shi-Qi Sun, Sheng-Ze Liang, Qi Huang and Jia-Zhong Sun |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jia-Zhong Sun, Chief, Professor, Department of Endocrinology, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuhan 430071, Hubei Province, China. sjz300@163.com |
| Key Words |
Methylation-specific PCR; Epigenetic biomarker; Lean population; Prediabetes; Type 2 diabetes mellitus; DNA methylation; Leptin gene promoter |
| Core Tip |
This study reveals progressive hypomethylation of the leptin (LEP) gene promoter in peripheral leukocytes of relatively lean Chinese adults (body mass index < 24 kg/m²) across glycemic states: (1) Normoglycemia (59.2%); (2) Prediabetes (43.6%); and (3) Type 2 diabetes mellitus (31.5%). The methylation decline correlated inversely with serum LEP levels (r = -0.95, P < 0.001), suggesting epigenetic dysregulation precedes metabolic dysfunction independent of obesity. These findings position LEP promoter methylation as a potential blood-based biomarker for early diabetes risk stratification in lean populations, highlighting its clinical utility for preventive strategies. |
| Publish Date |
2025-12-15 09:46 |
| Citation |
Sun SQ, Liang SZ, Huang Q, Sun JZ. Methylation status of leptin gene promoter in relatively lean Chinese adults with prediabetes and type 2 diabetes mellitus. World J Diabetes 2025; 16(12): 112789 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i12/112789.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i12.112789 |
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