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Articles Published Processes
1/20/2015 9:10:00 PM | Browse: 1070 | Download: 1137
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Received |
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2014-05-13 19:10 |
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Peer-Review Started |
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2014-05-13 20:45 |
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To Make the First Decision |
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2014-07-09 12:14 |
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Return for Revision |
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2014-07-14 08:31 |
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Revised |
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2014-07-30 01:16 |
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Second Decision |
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2014-09-19 08:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-09-19 09:48 |
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Articles in Press |
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2014-09-19 10:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-10-21 08:46 |
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Typeset the Manuscript |
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2015-01-12 13:31 |
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Publish the Manuscript Online |
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2015-01-20 20:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Autobiography |
| Article Title |
Antiproliferative effects of cinobufacini on human hepatocellular carcinoma HepG2 cells detected by atomic force microscopy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qing Wu, Wei-Dong Lin, Guan-Qun Liao, Li-Guo Zhang, Shun-Qian Wen and Jia-Ying Lin |
| Funding Agency and Grant Number |
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| Corresponding Author |
Wei-Dong Lin, Chief, Professor, Department of General Surgery, the Affiliated Foshan Hospital of South Medical University, No. 78 Weiguo Road, Foshan 528000, Guangdong Province, China. 13433123361@163.com |
| Key Words |
Cinobufacini; Cell viability; Atomic force microscopy; HepG2 cells; Hepatocarcinoma |
| Core Tip |
Cinobufacini is effective against hepatocarcinoma and. However its mechanism of action has not been determined. The present study investigated the effect of cinobufacini on HepG2 cells and the alterations in cell morphology and membrane ultrastructure. We used atomic force microscopy (AFM) to study the changes in cell membrane ultrastructure induced by cinobufacini. We demonstrated the AFM is a useful tool in verifying cell response to cinobufacini treatment. We observed nuclear morphology and actin filaments in the cytoskeleton by laser scanning confocal microscopy. The cellular changes allowed us to understand better the biophysical functions of HepG2 cells induced by cinobufacini. |
| Publish Date |
2015-01-20 20:12 |
| Citation |
Wu Q, Lin WD, Liao GQ, Zhang LG, Wen SQ, Lin JY. Antiproliferative effects of cinobufacini on human hepatocellular carcinoma HepG2 cells detected by atomic force microscopy. World J Gastroenterol 2015; 21(3): 854-861 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i3/854.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i3.854 |
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