| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Pathogenic analysis of post-transplantation obesity: A comprehensive systematic review
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ke-Ran Chen, Lin-Zhi Wu, Yi-Ning Huang, Si-Yu Zhuang, Ze-Yu Chen, Bin Xu and Tian-Cheng Xu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation, Youth Science Fund Project |
82305376 |
| the Youth Talent Support Project of the China Acupuncture and Moxibustion Association |
2024-2026ZGZJXH-QNRC005 |
| the 2024 Jiangsu Province Youth Science and Technology Talent Support Project |
JSTJ-2024-380 |
| 2025 Jiangsu Provincial Science and Technology Think Tank Program Project |
JSKX0125035 |
| Nanjing University of Chinese Medicine Innovation Training Program |
X202510315373 |
|
| Corresponding Author |
Tian-Cheng Xu, CEO, Chairman, Head, MD, PhD, President, Professor, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Qixia District, Nanjing 210023, Jiangsu Province, China. xtc@njucm.edu.cn |
| Key Words |
Organ transplantation; Obesity; Metabolic dysregulation; Immunopharmacology; Adipokine dysregulation axis; Inflammation-oxidation-adipogenesis loop |
| Core Tip |
Organ transplantation for end-stage failure faces post-transplant obesity, a key challenge. This review analyzes its multifactorial causes: Immunosuppressants (corticosteroids, calcineurin inhibitors) disrupt metabolism, hypoactivity worsens energy imbalance, poor diet promotes weight gain, and molecularly, immunosuppressants affect adipokines and insulin, with inflammation driving lipid accumulation. It offers a framework for mitigation strategies. |
| Publish Date |
2026-01-14 08:39 |
| Citation |
Chen KR, Wu LZ, Huang YN, Zhuang SY, Chen ZY, Xu B, Xu TC. Pathogenic analysis of post-transplantation obesity: A comprehensive systematic review. World J Transplant 2026; 16(1): 112811 |
| URL |
https://www.wjgnet.com/2220-3230/full/v16/i1/112811.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v16.i1.112811 |
