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Articles Published Processes
11/28/2025 3:10:33 AM | Browse: 12 | Download: 73
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Received |
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2025-08-07 02:30 |
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Peer-Review Started |
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2025-08-07 02:31 |
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First Decision by Editorial Office Director |
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2025-08-27 09:35 |
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Return for Revision |
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2025-08-27 09:35 |
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Revised |
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2025-09-28 07:17 |
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Publication Fee Transferred |
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2025-10-01 05:30 |
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Second Decision by Editor |
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2025-10-27 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-27 03:49 |
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Articles in Press |
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2025-10-27 03:49 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-21 01:29 |
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Publish the Manuscript Online |
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2025-11-28 03:10 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Anesthesiology |
| Manuscript Type |
Basic Study |
| Article Title |
Dexmedetomidine enhances anastomotic healing partly via the Wnt/β-catenin pathway in a rat model of colon surgery
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying Chen, Chun-Tian Li, Jie-Bo Wang, Wen-Lu Tang, Yu Zhao, Ye Chen, Lian-Ming Liao, Liang-Cheng Zhang, Tian-Hua Lin and Zhi-Fang Cao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fujian Province Natural Science Foundation |
No. 2021J011438 |
| Longyan City Science and Technology Plan Project |
No. 2022LYF17099 |
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| Corresponding Author |
Tian-Hua Lin, Department of Anaesthesiology, Longyan First Affiliated Hospital of Fujian Medical University, No. 105 Jiuyi North Road, Longyan 364000, Fujian Province, China. linthua2001@126.com |
| Key Words |
Intestinal anastomosis; Dexmedetomidine; Tight junction proteins; Wnt/β-catenin; Signaling pathway |
| Core Tip |
Dexmedetomidine (DEX), a selective α2-adrenergic agonist, significantly enhances anastomotic healing in rat models of colon surgery. Our study demonstrates that perioperative DEX administration improves intestinal barrier integrity by upregulating tight junction proteins (claudin-1/zonula occludens-1), reduces systemic inflammation (suppressed tumor necrosis factor-alpha/diamine oxidase/intestinal fatty acid-binding protein), and increases anastomotic burst pressure. Crucially, we identify activation of the Wnt/β-catenin pathway as a novel mechanistic driver for DEX-mediated repair. These findings reveal DEX’s dual role in barrier protection and regeneration, supporting its potential as a perioperative adjuvant to mitigate anastomotic leakage risk in abdominal surgery. |
| Publish Date |
2025-11-28 03:10 |
| Citation |
Chen Y, Li CT, Wang JB, Tang WL, Zhao Y, Chen Y, Liao LM, Zhang LC, Lin TH, Cao ZF. Dexmedetomidine enhances anastomotic healing partly via the Wnt/β-catenin pathway in a rat model of colon surgery. World J Gastroenterol 2025; 31(44): 112833 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i44/112833.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i44.112833 |
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