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Articles Published Processes
12/26/2025 10:27:30 AM | Browse: 2 | Download: 21
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Received |
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2025-08-08 06:57 |
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Peer-Review Started |
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2025-08-08 06:57 |
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First Decision by Editorial Office Director |
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2025-08-27 08:23 |
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Return for Revision |
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2025-08-27 08:23 |
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Revised |
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2025-09-10 04:26 |
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Publication Fee Transferred |
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2025-09-15 03:16 |
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Second Decision by Editor |
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2025-11-12 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-13 02:21 |
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Articles in Press |
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2025-11-13 02:21 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-18 02:18 |
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Publish the Manuscript Online |
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2025-12-26 10:27 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
He-He-Shu-Yang formula alleviates liver fibrosis by inhibiting hepatic stellate cell activation in vivo and in vitro
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fo-Lai Zeng, Mei-Jie Shi, You-Sheng Mo, Huan-Ming Xiao, Yu-Bao Xie and Xiao-Ling Chi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangdong Basic and Applied Basic Research Fund Project |
No. 2022A1515110825 and No. 2023A1515011092 |
| the Incubation Program for the Science and Technology Development of Chinese Medicine, Guangdong Laboratory |
No. HQL2024PZ033 |
| Chi Xiaoling National Famous Traditional Chinese Medicine Expert Inheritance Studio, Teaching Letter from the State Traditional Chinese Medicine Office[2022] |
No. 75 |
| Advantage Disease Project of Guangdong Provincial Hospital of Traditional Chinese Medicine[2020] |
No. 37 |
| Science and Technology Planning Project of Guangdong Province |
No. 2023B1212060063 |
| Project of Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases |
No. YN2023MB04 |
| Clinical Research Projects of Guangdong Provincial Hospital of Chinese Medicine |
No. YN2022QN05 |
| Guangzhou Basic Research Program for Young Doctors in Basic and Applied Basic Research |
No. 2024A04J3004 |
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| Corresponding Author |
Xiao-Ling Chi, Chief Physician, Department of Hepatology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111 Dade Road, Guangzhou 510120, Guangdong Province, China. chixiaolingqh@163.com |
| Key Words |
He-He-Shu-Yang formula; Liver fibrosis; Mechanism; Hepatic stellate cells; Nicotinamide adenine dinucleotide phosphate oxidase 4 pathway; Reactive oxygen species pathway |
| Core Tip |
High-performance liquid chromatography identified six key components in He-He-Shu-Yang formula (HHSY) that are effective in reducing liver fibrosis. HHSY has a definite therapeutic effect on liver fibrosis in vivo and in vitro models. HHSY’s mechanism may be through the inhibition of hepatic stellate cell activation via the nicotinamide adenine dinucleotide phosphate oxidase 4/reactive oxygen species/nucleotide binding oligomerization domain-like receptor family pyrin domain-containing 3 pathways. |
| Publish Date |
2025-12-26 10:27 |
| Citation |
Zeng FL, Shi MJ, Mo YS, Xiao HM, Xie YB, Chi XL. He-He-Shu-Yang formula alleviates liver fibrosis by inhibiting hepatic stellate cell activation in vivo and in vitro. World J Hepatol 2025; 17(12): 112835 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i12/112835.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i12.112835 |
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