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Articles Published Processes
11/14/2025 12:56:24 AM | Browse: 12 | Download: 69
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Received |
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2025-08-07 02:24 |
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Peer-Review Started |
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2025-08-07 02:24 |
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First Decision by Editorial Office Director |
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2025-09-04 10:39 |
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Return for Revision |
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2025-09-06 08:41 |
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Revised |
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2025-09-19 15:02 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-27 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-27 07:12 |
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Articles in Press |
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2025-10-27 07:12 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-05 00:45 |
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Publish the Manuscript Online |
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2025-11-14 00:56 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
RSPO3 rearrangements in advanced colorectal cancer patients and their relationship with disease characteristics
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Raquel Tur, Mar Abad, Elena Filipovich, Maria Belen Rivas, Marta Rodriguez, Juan Carlos Montero and José María Sayagués |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
José María Sayagués, Senior Scientist, Department of Pathology-University Hospital of Salamanca, Institute of Biomedical Research of Salamanca, Paseo de San Vicente, 58-182, Salamanca 37007, Spain. ppmari@usal.es |
| Key Words |
Advanced colorectal cancer; Next-generation sequencing; Protein tyrosine phosphatase receptor type k::R-spondin 3 fusion; Wnt signaling; Genomic alterations |
| Core Tip |
In our study, we identified key genomic alterations in advanced colorectal cancer using next-generation sequencing. The most frequent mutations occurred in tumor protein p53, Kirsten rat sarcoma viral oncogene homolog, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, B-Raf kinase, and fibroblast growth factor receptor 3, with distinct mutational patterns observed between tumors originating in the left and right colon. Notably, protein tyrosine phosphatase receptor type k::R-spondin 3 fusion were detected in 8% of cases, predominantly in right-sided tumors, and were associated with poorer overall survival, supporting their relevance as both a biomarker and therapeutic target. Larger prospective studies are needed to confirm their clinical utility in colorectal cancer. |
| Publish Date |
2025-11-14 00:56 |
| Citation |
Tur R, Abad M, Filipovich E, Rivas MB, Rodriguez M, Montero JC, Sayagués JM. RSPO3 rearrangements in advanced colorectal cancer patients and their relationship with disease characteristics. World J Gastrointest Oncol 2025; 17(11): 112838 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i11/112838.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i11.112838 |
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