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Articles Published Processes
3/26/2026 9:22:56 AM | Browse: 159 | Download: 560
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Received |
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2025-08-08 05:49 |
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Peer-Review Started |
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2025-08-08 05:49 |
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First Decision by Editorial Office Director |
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2025-09-09 10:01 |
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Return for Revision |
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2025-09-09 10:01 |
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Revised |
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2025-09-29 19:57 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-24 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-24 03:45 |
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Articles in Press |
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2025-12-24 03:45 |
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Edit the Manuscript by Language Editor |
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2025-12-30 23:19 |
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Typeset the Manuscript |
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2026-03-16 00:51 |
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Publish the Manuscript Online |
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2026-03-26 09:22 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Case Control Study |
| Article Title |
Immunogenetic and molecular biomarkers in COVID-19 and hepatitis C virus infection: Evaluating HLA (rs1131500), IGF-2 and I-FABP for diagnostic potential
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Amal Ahmed Mohamed, Rasha M Abdel-Hamid, Amr Amin, Eman Al Hussain A Gawad, Salma Mohamed Saed, Dalia A Gaber, Mohamed Ahmed Ezz Al Arab, Waleed El-Agawy, Mohammed Zakaria Ali AbuRahma, Heba Ahmed Elosaily, Elsaeed E Shaaban, Shaymaa A Ismail and Amany A Sakr |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Amany A Sakr, PhD, Department of Biotechnology, BENI-SUEF UNIVERSITY, Department of Biotechnology, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Egypt. Electronic address: amanyawad29_sd@psas.bsu.edu.eg, Beni-Suef 62521, Egypt. amanyawad29_sd@psas.bsu.edu.eg |
| Key Words |
COVID-19; Hepatitis C virus; Immunogenetics; Human leukocyte antigen (rs1131500); Insulin-like growth factor-2; Intestinal fatty acid binding protein; Biomarkers |
| Core Tip |
This study identifies insulin-like growth factor 2 as a robust molecular biomarker for distinguishing between coronavirus disease 2019 (COVID-19), hepatitis C virus, and co-infection, with the highest diagnostic performance in co-infected individuals. Intestinal fatty acid binding protein showed selective utility in co-infections, while interferon-gamma displayed a protective association. Genotyping of human leukocyte antigen rs1131500 revealed the TT genotype as more frequent in COVID-19 and co-infection cases, suggesting a potential immunogenetic risk factor. These findings provide new insight into host immune responses and offer clinically relevant biomarkers for diagnosis and personalized management of viral infections. |
| Publish Date |
2026-03-26 09:22 |
| Citation |
Mohamed AA, Abdel-Hamid RM, Amin A, A Gawad EAH, Saed SM, Gaber DA, Ezz Al Arab MA, El-Agawy W, AbuRahma MZA, Elosaily HA, Shaaban EE, Ismail SA, Sakr AA. Immunogenetic and molecular biomarkers in COVID-19 and hepatitis C virus infection: Evaluating HLA (rs1131500), IGF-2 and I-FABP for diagnostic potential. World J Hepatol 2026; 18(3): 112850
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i3/112850.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i3.112850 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
