| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Patients with primary sclerosing cholangitis with and without end-stage liver disease have similar outcomes after liver transplantation
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Mojmir Hlavaty, Jan Brezina, Pavel Wohl, Istvan Modos, Lukas Bajer, Ondrej Fabian, Andrea Vajsova, Tomas Hucl and Pavel Drastich |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Health of the Czech Republic in cooperation with the Czech Health Research Council |
No. NU21J-06-00027 and No. NU22-06-00269 |
| Ministry of Health, Czech Republic (Institute for Clinical and Experimental Medicine) |
No. IN 00023001 |
|
| Corresponding Author |
Pavel Drastich, Associate Professor, MD, PhD, Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 14021, Czech Republic. padr@ikem.cz |
| Key Words |
Primary sclerosing cholangitis; Liver transplant; Recurrence of primary sclerosing cholangitis; Cytomegalovirus; Acute cellular rejection; Overlap syndrome; Graft failure |
| Core Tip |
This study demonstrated the outcomes of liver transplantation (LT) recipients with primary sclerosing cholangitis (PSC) and risk factors for recurrence of PSC (rPSC) and graft failure. Patients with PSC undergoing LT for end-stage liver disease have similar rPSC rates, graft failure rates, and overall survival comparable to those undergoing LT for non-end-stage liver disease indications (e.g., recurrent bacterial cholangitis). Acute cellular rejection, cytomegalovirus infection, and longer postoperative hospitalization were associated with both rPSC and graft failure. Identification of risk factors is necessary to better understand the pathogenesis of rPSC. |
| Publish Date |
2026-03-26 09:22 |
| Citation |
Hlavaty M, Brezina J, Wohl P, Modos I, Bajer L, Fabian O, Vajsova A, Hucl T, Drastich P. Patients with primary sclerosing cholangitis with and without end-stage liver disease have similar outcomes after liver transplantation. World J Hepatol 2026; 18(3): 112934 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i3/112934.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i3.112934 |
