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Articles Published Processes
12/11/2025 8:20:56 AM | Browse: 3 | Download: 14
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Received |
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2025-08-11 01:23 |
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Peer-Review Started |
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2025-08-11 01:23 |
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First Decision by Editorial Office Director |
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2025-09-03 10:07 |
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Return for Revision |
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2025-09-03 22:09 |
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Revised |
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2025-09-14 13:23 |
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Publication Fee Transferred |
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2025-09-18 21:53 |
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Second Decision by Editor |
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2025-10-31 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-31 08:43 |
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Articles in Press |
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2025-10-31 08:43 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-01 11:15 |
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Publish the Manuscript Online |
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2025-12-11 08:20 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Geriatrics & Gerontology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Tumor-resident microorganisms as clinical biomarkers in primary liver cancer: A systematic review of current evidence
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shuai Song, Li-Shan Xu, Lin-Qing Wang, Xiu Zhou, Xin Jiang and Chang-Ping Li |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xin Jiang, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310000, Zhejiang Province, China. jx10818030@zju.edu.cn |
| Key Words |
Intratumoral microbiota; Hepatocellular carcinoma; Intrahepatic cholangiocarcinoma; Diagnosis; Prognosis; Therapeutic response; Gut-liver axis; 16S rRNA sequencing; Biomarkers; Systematic review |
| Core Tip |
Once considered sterile environments, hepatic malignancies are now recognized to harbor distinct microbial communities with significant clinical implications. This systematic review of 20 high-quality studies demonstrates that intratumoral microbes represent promising biomarkers across multiple applications in liver cancer. Specific bacterial taxa achieved exceptional diagnostic accuracy (area under the curve > 0.9), while microbial diversity patterns showed consistent prognostic associations with patient survival outcomes. Mechanistic investigations revealed microbe-mediated oncogenic pathway activation, immune modulation, and drug resistance mechanisms. These findings position tumor-resident microorganisms at the threshold of clinical translation, offering novel opportunities for precision diagnosis, prognostic stratification, and personalized treatment strategies in hepatic malignancy management. |
| Publish Date |
2025-12-11 08:20 |
| Citation |
Song S, Xu LS, Wang LQ, Zhou X, Jiang X, Li CP. Tumor-resident microorganisms as clinical biomarkers in primary liver cancer: A systematic review of current evidence. World J Gastrointest Oncol 2025; 17(12): 112936 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i12/112936.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i12.112936 |
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