| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Observational Study |
| Article Title |
Sustained anxiolytic and antidepressant effects of botulinum toxin A in blepharospasm patients beyond motor symptom control
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Xin-Yi He, Min-Ye Xu, Li-Ying Feng, Jian-Ting Zhang, Li-Zuo Jin, Ling Jin, Jian-Chao Ge, Liang Zhang, Wen-Bin Zhang, Li Zhang, Hong Shen and Jun Yan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Special Funds of Jiangsu Provincial Key Research and Development Projects |
BE2019612 |
| Scientific Research Project Cooperated by Lanzhou Biotechnology Development Co., Ltd. |
|
| Key R&D Program of Jiangsu Science and Technology Project |
BE2022049, BE2022049-1 |
| National Natural Science Foundation of China |
82171249 |
| Nanjing Rehabilitation Medicine Center Project |
|
| Jiangsu Provincial Health Commission Special Fund for Aging and Health |
|
|
| Corresponding Author |
Jun Yan, Chief Physician, MD, Department of Geriatrics, Affiliated Brain Hospital of Nanjing Medical University, No. 264 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. yanjun2008@njmu.edu.cn |
| Key Words |
Botulinum toxin A; Repeated injection; Neuromuscular junction; Anxiety; Depression; Blepharospasm |
| Core Tip |
Botulinum toxin A (BoNT-A) injection significantly decreases subscale scores of Self-rating Anxiety Scale and Self-rating Depression Scale in blepharospasm even after its effects on facial muscle activity have subside. BoNT-A treatment is an independent factor for the depressive symptom improvement, especially, well-being index in the certain state. BoNT-A might alleviate somatic anxiety but not mental anxiety at a relative long follow-up. Repeated BoNT-A treatment may improve the anxiety and depressive symptoms. |
| Publish Date |
2025-12-31 05:47 |
| Citation |
He XY, Xu MY, Feng LY, Zhang JT, Jin LZ, Jin L, Ge JC, Zhang L, Zhang WB, Zhang L, Shen H, Yan J. Sustained anxiolytic and antidepressant effects of botulinum toxin A in blepharospasm patients beyond motor symptom control. World J Psychiatry 2026; 16(1): 112973 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i1/112973.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i1.112973 |
