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Articles Published Processes
12/17/2025 6:45:14 AM | Browse: 6 | Download: 12
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Received |
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2025-08-13 01:32 |
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Peer-Review Started |
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2025-08-13 01:32 |
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First Decision by Editorial Office Director |
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2025-08-20 07:33 |
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Return for Revision |
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2025-08-20 07:33 |
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Revised |
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2025-08-30 03:25 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-29 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-29 06:51 |
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Articles in Press |
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2025-10-29 06:51 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-08 07:02 |
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Publish the Manuscript Online |
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2025-12-17 06:45 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Minireviews |
| Article Title |
Nanofiber scaffold for bone tissue engineering: Mechanism, challenge and future prospect
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rui-Ming Wen, Hai-Xia Wang, Zhi-Jun Liu and Zi-Qiang Duan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zi-Qiang Duan, MD, Department of Rehabilitation, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No. 1 People’s Hospital, No. 48 Taling South Road, Jiujiang 332000, Jiangxi Province, China. dzq10353@163.com |
| Key Words |
Nanofibrous scaffolds; Triple synergistic regulation; Bone regeneration; Mechanobionics; Precision bone tissue engineering |
| Core Tip |
Nanofiber scaffold accurately mimics the topological structure of natural bone extracellular matrix, and regulates the behavior of bone marrow mesenchymal stem cells through physical topological guidance, biochemical signal activation and mechanical microenvironment programming, providing a dynamic adjustable platform for bone defect repair. However, clinical transformation is restricted by bottlenecks such as functional factor delivery, vascularization and mechanical adaptation. This review analyzes the triple coordinated regulation network and dynamic interaction mechanism, evaluates the transformation prospects of intelligent materials and bionic design, and provides theoretical support for the research and development of precise bone regeneration strategies. |
| Publish Date |
2025-12-17 06:45 |
| Citation |
Wen RM, Wang HX, Liu ZJ, Duan ZQ. Nanofiber scaffold for bone tissue engineering: Mechanism, challenge and future prospect. World J Orthop 2025; 16(12): 112998 |
| URL |
https://www.wjgnet.com/2218-5836/full/v16/i12/112998.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v16.i12.112998 |
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